Pharm Labs aseptic compounds

Parental product

drugs, vaccines, or IV fluids which are administered into the vascular space (bloodstream), cerebrospinal fluid, muscle, or tissues.

Sterile

The products must be what?

Aseptic compounding

the process of mixing two or more sterile products without introducing contamination.

Pharmacist responsibilities

Use proper aseptic techniques to maintain product sterility.

Supervise pharmacy technicians to ensure they follow proper aseptic procedures.

Use syringes correctly to accurately transfer the required amount.

the following texts relates to what?

the compounder touch (u touching it)

The most common source of product contamination is

The solutions

Wash your hands thoroughly and wear gloves.

Disinfect the gloves with alcohol before compounding.

Disinfect the vial stopper and bag injection port with alcohol before compounding.

Do not touch critical sites during compounding, even if wearing gloves.

Maintain critical sites in high-speed, HEPA-filtered airflow throughout compounding

dirty air

The 2nd most common source of contamination is

High-Efficiency Particulate Air Filter (HEPA)

To clean air, use what filter?

primary engineering controls

Clean room & a hood

Air

Maintain critical sites in high-speed, HEPA-filtered air flow throughout the compounding procedure.

Horizontal Laminar Airflow Workbench (LAFW)

blows air in laminar flow from back to front

proper tech reduce contaminants entering hood from the open side

laminar flow

the air goes out in a straight line

Vertical LAFW

laminar air flows from top to bottom

Critical sites

1) surface that must never be touched

2) must never be touched after disinfecting

unimpeded air (1st air)

air out of the HEPA filter

unimpeded air (1st air)

The critical site surface must always receive ____ flow while compounded

vial stopper

A critical site to disinfect at the top

needle hub

A critical site to never touch the colored portion.

exposed needle

A critical site to never touch the open needle

syringe tip

A critical site to never touch the tip of the syringe

bag injection port

A critical site to disinfect the medication port

medication port (white above blue)

Within the injection bag, which port must be closer to the HEPA filter?

injection bag & vial 

The closet things to the HEPA filter

Opening the syringe, then needle

When receiving 1st air, what is the recommendation?

needle, syringe, vial, bag, swab

The supplies needed are …

Supply distribution

The 1st step in the hood is

Never work or pass over the top of critical sites

What is the following advice to prevent air turbulence?

Push & twist

1 mL syringes contain slip tip making the needle loosely fitted to the syringe, so what is the advice to seat the needle tightly?

~0.1 mL less air than the total

When drawing up the correct volume of air, you draw up how much

1.4 mL

If needing 1.5 mL of liquid, you inject how much air?

0.4 mL

If needing 0.5 mL of liquid, you inject how much air?

vertically

the needle must be inserted in what manner?

Bubbling air through the solution

When withdrawing the correct volume from vial, you must avoid what

Straight into the tube, through the white tube & septum

What is the correct way to insert the needle into the syringe? 

0.01 mL

image not drawn to scale

Each tick mark within a 1 mL syringe is … 

0.1 mL

image not drawn to scale

Each tick mark in the 3mL syringe is … 

0.2 mL

image not drawn to scale

Each tick mark within the 5 mL is …

where the plunger contacts the syringe barrel

Where do you read the syringe volume?

0.05 mL

The dead space volume for every syringe

dead-volume

The amount that remains in the syringe tip and needle is referred to as

red sharps containers

When cleaning up, the needles go in…

For protection against stick

Why do we require long pants and closed-toe shoes?

To prevent exposure/contamination

When preparing a parenteral product, what is the point of using the proper aseptic technique?

6 inches

What is the minimum working distance inside a horizontal laminar airflow hood?

Over pressurization

What does it mean when you insert the needle into the bag and you find it difficult to advance the needle up to the hub?

1

How many septa in an IV bag must be passed through when injecting the volume into the bag?

Allows precise measurements for smaller volumes

How is the construction of the 1 mL syringe (green wrapper) different from the 3 and 5 mL syringes?

small bubbles are not dangerous for patients

Explain why it's not necessary to eliminate all air bubbles from a syringe before giving it to a patient.

vial headspace

The gas-filled area between the liquid and the rubber closure in a vial

Because it ruins the solution through contamination

Explain why we try to avoid bubbling air through a drug solution.