Anti-Inflammatory Drugs for Final

NSAIDs:

salicylates, propionic acid derivatives, Cox-2 inhibitors, used for mild to moderate headache, post op pain, gout, RA, OA, action- inhibits leukotriene pathway or prostaglandin pathway, blocks chemical activity of the enzyme COX, contraindications- patients with aspirin allergy, vitamin K deficiency, peptic ulcer disease, adverse effects- GI upset, renal failure, MI and stroke, hepatotoxicity, tinnitus, all NSAIDs carry a black box warning regarding an increased risk of adverse cardiovascular events such as MI and stroke

Salicylates:

action- inhibit platelet aggregation, shown to reduce cardiac death after MI, not used in children due to Reye’s syndrome, toxicity- increased heart rate, hearing loss, tinnitus, mental confusion

Propionic Acid Derivatives:

ibuprofen and naproxen

COX-2 inhibitors:

developed to decrease GI toxicity

Adverse effects of NSAIDs:

GI bleeding, renal failure and pulmonary edema

Nursing implications of NSAIDs:

GI lesions or peptic ulcer disease, bleeding disorders, better taken with food or milk, inform patients to be aware of any unusual bleeding or blood in the stool, enteric coated tablets should not be chewed or crushed