A&P Ch 23.1: Digestive Anatomy: GI Tract

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104 Terms

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Functions of the digestive system:

1. Ingestion of food
2. Propulsion of food through GI tract (includes peristalsis)
3. Mechanical digestion
4. Chemical digestion
5. Absorption
6. Defecation
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Peristalsis
Alternate waves of contraction and relaxation
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Mechanical digestion
Physical mixing of food with digestive enzymes
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Chemical digestion
Catalyzed by enzymes
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Absorbtion
Uptake of small molecules though intestinal lining
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Defecation
Elimination of feces or stool
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Portions of the digestive system: Gastrointestinal (GI) Tract
oral cavity → pharynx (oro & laryngo- pharynx) → esophagus → stomach → small intestine → large intestine
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Portions of the digestive system: Accessory organs
Salivary glands, liver, gallbladder & pancreas
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What are the serous membranes of the abdomen?

1. Peritoneum
2. Retroperitoneal structures
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Parts of the peritoneum:
Visceral and parietal peritoneum
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Visceral peritoneum
Adheres to the surface of abdominal organs
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Parietal peritoneum
Adheres to the wll of the abdominal cavity
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Some portions of the peritoneum have different names:

1. Omentum
2. Mesocolon
3. Mesentary
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Omentum
Associated with stomach
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Mesocolon
Associated with large intestine
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Mesentary
Associated with small intestine
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Retroperitoneal structures
These structures are located against posterior wall behind the parietal peritoneum. This keeps them fixed in place.
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What are the retroperitoneal structures?
Aorta & IVC, kidneys, pancreas, duodenum, and some portions of large intestine
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Layers of the GI Tract wall
\*4 layers that are present from the esophagus to the rectum.


1. Mucosa
2. Submucosa
3. Muscularis externa
4. Adventitia or serosa
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Mucosa structure:
Innermost layer; lines the hollow lumen
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What does the mucosa contain?
Epithelium, lamina propria, & muscularis mucosae
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Epithelium
Simple columnar epithelium in stomach and intestines
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Lamina propria
Connective tissue; also capillaries for nourishment & absorption; & lymphatic tissue to defend against pathogens
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Muscularis mucosae
Thin layer of smooth muscle around lamina propria
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What are the function of the mucosa?
Secretion of mucus, digestive enzymes, and hormones ; absorption of the end products of digestion ; protection against pathogens in food
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Submucosa
Connective tissue layer containing blood and lymphatic vessels, nerve fibers, and lymphatic tissue
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Muscularis externa
Two layers of smooth muscle being:

a. inner circular muscularis (INC) \n b. outer longitudinal muscularis (OUL)
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What are the functions of the muscularis externa?

1. Responsible for muscular contractions (including peristalis) which:

a. move food along GI tract

b. mix food with GI tract secretions

c. physically break down food
2. Thickens at some points to form sphincters
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Adventitia
Outer layer of GI tract above diaphragm specifically around esophagus
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What is adventitia composed of?
Fibrous connective tissue
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Serosa
Outer layer of GI tract below diaphragm, specifically around stomach and intestines
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What is serosa composed of?
A serous covering that binds/anchors GI tract. Same as visceral peritoneum
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What is the oral cavity responsible for?
Chewing & mixing food with saliva ; initiating chemical digestion of carbohydrates by an enzyme called salivary amylase
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Pharynx
Passageway carrying chewed food (bolus) from oral cavity to esophagus; performs no additional chemical digestion
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Esophagus
Tube that carries food from pharynx to stomach; performs no chemical digestion
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Esophageal hiatus
Point where esophagus penetrates diaphragm
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Cardiac (gastroesophageal) sphincter
Thickening of the muscularis just above stomach
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Functions of the stomach:

1. Stores food
2. Mixes food with gastric secretions
3. Initiates protein digestion
4. Limited absorption (ex. absorbs alcohol + aspirin)
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Gross anatomy of the stomach
Cardiac region (cardia), fundus, body, pyloric region. pyloric sphincter (rugae, lesser curvature, greater curvature)
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Cardiac region
Surrounds the entrance of esophagus
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Fundus
Dome shaped; bulges superiorly & laterally to the cardia region
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Body
Large middle portion of the stomach
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Pyloric region
Funnel-shaped portion of the stomach leading into duodenum
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Pyloric sphincter
Between stomach and duodenum; a valve that controls movement of food
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Rugae
Large folds of mucosa ( and submucosa) present in stomach wall when empty
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Lesser curvature
Concave, medial surface of the stomach
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Greater curvature
Convex, lateral surface of the stomach
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What does the stomach wall contain?
An extra oblique muscle layer in the muscularis (+ INC & OUL) ; gastric pits, which contain glands that make gastric juice
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Cells of the gastric glands:
Mucous neck cells, parietal cells, chief cells, enteroendocrine (G) cells
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Mucous neck cells
Secrete thin, acidic mucus
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Parietal cells
Secrete HCI and intrinsic factor
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HCI (hydrochloric acid)
Activates pepsinogen
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Intrinsic factor
Aids in absorbtion of vitamin B12
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Chief cells
Secrete pepsinogen, an inactive enzyme that's converted to pepsin by HCI in the lumen
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Pepsin
A protein-digesting enzyme
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Enteroendocrine (G) cells
Secrete a hormone called gastrin into the blood that stimulates secretion of gastric juice
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Summary of the stomach:
Food enters stomach as a bolus and leaves as chyme, a semi-fluid mixture that passes through the pyloric sphincter
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What is the hostile environment of the stomach?
Extremely acidic; contains protein-digesting enzymes; few pathogens can survive
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Mucosal barrier of the stomach:
Protects stomach from it's own harsh internal environment
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The mucosal barrier of the stomach is formed by:
Mucus coat and tight junctions between epithelial cells
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Mucus coat
Thick, bicarbonate-rich mucus is built up on the stomach wall
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Tight junctions between epithelial cells
Prevent gastric juice from leaking into underlying tissues
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What are the function of the small intestine?

1. Primary digestive organ
2. Primary sight of absorption
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What does the small intestine being the primary digestive organ mean?
Completes digestion of carbohydrates and proteins ; performs digestion of lipids (fats)
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Portions of the small intestine:
Duodenum, jejunum, ileum
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Duodenum
Receives chyme from stomach ; most chemical digestion occurs here ; also receives secretions from pancreas, liver & gallbladder ; contain Brunner's (duodenal) glands in submucosa
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Brunner's (duodenal) glands in submucosa
Secrete alkaline mucus to neutralize acidic incoming chyme
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Jejunum
2nd portion of small intestine
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Ileum
Distal segment; carries chyme to large intestine
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What are the structural modifications of the small intestine?
Circular folds, villi, and microvilli
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Circular folds
Large folds of mucosa and submucosa
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Villi
Fingerlike projections of mucosa
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Microvilli
"brush border" : tiny projections of the intestinal mucosal cell's plasma membrane
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What is the function of the 3 modifications?
They all increase surface area for absorbtion
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Histology of the small intestine
Have tight junctions between absorptive columnar cells; many goblet cells \= secrete mucus ; enteroendocrine cells - secrete 2 hormones
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What 2 hormones do enteroendocrine cells secrete in the small intestine?
Secretin and cholecystokinin
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Other features of the small intestine:
Intestinal crypts, peyer's patches, capillaries, lacteals
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Intestinal crypts
Pockets between the villi that secrete intestinal juice (watery mixture w/ mucus)
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Peyer's patches
Aggregations of lymphoid tissue → prevent bacteria of intestine from entering blood
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Capillaries
In villi; transport absorbed sugars and amino acids
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Lacteals
Lymphatic capillaries in villi that transport absorbed fats
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What are the functions of the large intestine?

1. Absorption of some water and electrolytes
2. Defecation (elimination of feces)
3. Vitamin K and folic acid production - by bacteria within the large intestine
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Feces
Undigested food residues, mucus, sloughed-off epithelial cells, bacteria, and some water
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What are the 5 regions of the large intestine?

1. Cecum
2. Appendix
3. Colon
4. Rectum
5. Anal canal
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Cecum
Pouch below the junction of the large intestine within the ileum
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Illeocecal valve
Opening between ileum and cecum
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Appendix
Blind-ended, wormlike extension attached to medial surface of cecum; contains lymphoid tissue
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Colon
Extends from ileocecal valve to rectum
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Portions of the colon:
a. Ascending colon

b. hepatic flexure

c. transverse colon

d. Splenic flexure

e. Descending colon

f. Sigmoid colon
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Ascending colon
Travels up right side of colon
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Hepatic flexure
Bend near liver of colon
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Transverse colon
Travels across abdomen from right to left of colon
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Splenic flexure
Bend near spleen of colon
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Descending colon
Travels down left side of colon
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Sigmoid colon
Curves around iliac fossa and connects to the rectum
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Rectum
Portion of GI tract running between sigmoid colon & anal canal; begins in the region of the sacrum and runs anterior to the sacrum
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What does the rectum contain?
Rectal valves which separate feces from flatus (gas)
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Anal canal
Final inch ( ≈3cm) of large intestine; most distal portion of GI tract
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Anus
Opening of anal canal
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Internal anal sphincter
Smooth muscle; under autonomic control