1. Ingestion of food 2. Propulsion of food through GI tract (includes peristalsis) 3. Mechanical digestion 4. Chemical digestion 5. Absorption 6. Defecation
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Peristalsis
Alternate waves of contraction and relaxation
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Mechanical digestion
Physical mixing of food with digestive enzymes
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Chemical digestion
Catalyzed by enzymes
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Absorbtion
Uptake of small molecules though intestinal lining
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Defecation
Elimination of feces or stool
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Portions of the digestive system: Gastrointestinal (GI) Tract
oral cavity → pharynx (oro & laryngo- pharynx) → esophagus → stomach → small intestine → large intestine
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Portions of the digestive system: Accessory organs
Salivary glands, liver, gallbladder & pancreas
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What are the serous membranes of the abdomen?
1. Peritoneum 2. Retroperitoneal structures
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Parts of the peritoneum:
Visceral and parietal peritoneum
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Visceral peritoneum
Adheres to the surface of abdominal organs
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Parietal peritoneum
Adheres to the wll of the abdominal cavity
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Some portions of the peritoneum have different names:
1. Omentum 2. Mesocolon 3. Mesentary
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Omentum
Associated with stomach
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Mesocolon
Associated with large intestine
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Mesentary
Associated with small intestine
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Retroperitoneal structures
These structures are located against posterior wall behind the parietal peritoneum. This keeps them fixed in place.
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What are the retroperitoneal structures?
Aorta & IVC, kidneys, pancreas, duodenum, and some portions of large intestine
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Layers of the GI Tract wall
\*4 layers that are present from the esophagus to the rectum.
Secrete pepsinogen, an inactive enzyme that's converted to pepsin by HCI in the lumen
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Pepsin
A protein-digesting enzyme
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Enteroendocrine (G) cells
Secrete a hormone called gastrin into the blood that stimulates secretion of gastric juice
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Summary of the stomach:
Food enters stomach as a bolus and leaves as chyme, a semi-fluid mixture that passes through the pyloric sphincter
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What is the hostile environment of the stomach?
Extremely acidic; contains protein-digesting enzymes; few pathogens can survive
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Mucosal barrier of the stomach:
Protects stomach from it's own harsh internal environment
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The mucosal barrier of the stomach is formed by:
Mucus coat and tight junctions between epithelial cells
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Mucus coat
Thick, bicarbonate-rich mucus is built up on the stomach wall
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Tight junctions between epithelial cells
Prevent gastric juice from leaking into underlying tissues
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What are the function of the small intestine?
1. Primary digestive organ 2. Primary sight of absorption
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What does the small intestine being the primary digestive organ mean?
Completes digestion of carbohydrates and proteins ; performs digestion of lipids (fats)
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Portions of the small intestine:
Duodenum, jejunum, ileum
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Duodenum
Receives chyme from stomach ; most chemical digestion occurs here ; also receives secretions from pancreas, liver & gallbladder ; contain Brunner's (duodenal) glands in submucosa
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Brunner's (duodenal) glands in submucosa
Secrete alkaline mucus to neutralize acidic incoming chyme
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Jejunum
2nd portion of small intestine
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Ileum
Distal segment; carries chyme to large intestine
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What are the structural modifications of the small intestine?
Circular folds, villi, and microvilli
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Circular folds
Large folds of mucosa and submucosa
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Villi
Fingerlike projections of mucosa
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Microvilli
"brush border" : tiny projections of the intestinal mucosal cell's plasma membrane
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What is the function of the 3 modifications?
They all increase surface area for absorbtion
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Histology of the small intestine
Have tight junctions between absorptive columnar cells; many goblet cells \= secrete mucus ; enteroendocrine cells - secrete 2 hormones
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What 2 hormones do enteroendocrine cells secrete in the small intestine?
Pockets between the villi that secrete intestinal juice (watery mixture w/ mucus)
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Peyer's patches
Aggregations of lymphoid tissue → prevent bacteria of intestine from entering blood
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Capillaries
In villi; transport absorbed sugars and amino acids
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Lacteals
Lymphatic capillaries in villi that transport absorbed fats
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What are the functions of the large intestine?
1. Absorption of some water and electrolytes 2. Defecation (elimination of feces) 3. Vitamin K and folic acid production - by bacteria within the large intestine
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Feces
Undigested food residues, mucus, sloughed-off epithelial cells, bacteria, and some water