Exam 1 - Osteogenesis Imperfecta, osteopetrosis, osteoporosis

what does Type I osteogenesis imperfecta result in? why?

brittle bones

altered type I collagen

is type II osteogenesis imperfecta compatible with life

no

t/f

osteogenesis imperfecta is a contraindication to manual adjusting

true

is osteogenesis imperfecta idiopathic or inherited?

inherited

what are some key characteristics of osteogenesis imperfecta

blue sclerae, zebra stripe sign

Osteopetrosis is a group of inherited disorders involving increase in ___ of bone

density/sclerosis

what does osteopetrosis lead to

decreased blood cells causing fatigue and frequent infections

increased fractures

which is affected in osteopetrosis: osteoblast or osteoclast? is activity reduced or increased?

reduced osteoclast

reduced osteoclast activity in osteopetrosis causing ___ in density and ___ in strength of bone

increase, decrease

is osteopetrosis idiopathic or inherited

inherited

Osteoporosis is a ___ loss of bone density while Osteopenia is a ___ loss of bone density

severe, mild

osteoporosis primarily affects what bone

trabecular spongy bone of vertebral bodies, femoral neck, and calcaneus

Is t-score or z-score more commonly used for determining osteoporosis vs. osteopenia

t-score

primary osteoporosis is seen in which populations

senile and postmenopausal

when is peak bone mass

age 25-30

why do postmenopausal women typically develop osteoporosis

decreased estrogen and increased osteoclast activity

why does aging typically lead to osteoporosis

decreased activity of osteoblasts and reduced physical activity

are x-rays diagnostic of osteoporosis

no

what are some ways to prevent osteoporosis

physical activity, calcium, vitamin d

osteoporosis is classified by what DEXA t-score

-2.5

is senile or postmenopausal osteoporosis more common?

postmenopausal