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urinary system
kidneys, ureters, urinary bladder, urethra
cleanse the blood of nitrogenous wastes, toxins, excess ions and water, and other unnecessary or undesirable substances by forming urine
maintain proper chemical composition of the blood and other body fluids (regulate blood volume)
functions of kidneys
urea, uric acid, creatinine
What are nitrogenous compounds (main waste products) excreted in urine?
urea
waste derived from breakdown of amino acids during normal recycling of body's proteins
uric acid
waste from turnover of nucleic acids
creatinine
waste formed by the breakdown of creatine phosphate, a molecule in muscle that stores energy for ATP production
ureters
The tubes that carry urine from the kidneys to the bladder.
urinary bladder
temporary storage reservoir for urine
urethra
tube that carries urine to body exterior
superior lumbar region of the posterior abdominal wall
Where do the kidneys lie?
right kidney
which kidney is crowded by the liver and lies slightly inferior compared to the other kidney?
renal hilum
A medial indentation where several structures enter or exit the kidney (ureters, renal blood vessels, and nerves)
renal capsule, adipose capsule, renal fascia
What are the layers that surround each kidney from deep to superficial?
renal capsule
fibrous capsule made up of dense connective tissue layer of collagen fibers, adheres to kidney's surface
maintains the shape of the kidney
forms a barrier to inhibit the spread of infection
provides mechanical protection
adipose capsule
also known as perirenal fat
layer of fat around the kidney - provides cushion
renal fascia
dense outer layer formed by collagen fibers that extend outward from the inner renal (fibrous) capsule through the adipose capsule
anchors the kidney to surrounding structures
posteriorly - bound to deep fascia surrounding the muscles of body wall
anteriorly - it is attached to the peritoneum and to the anterior renal fascia of the opposite end
pararenal fat
outermost layer between renal fascia and peritoneum
separates the posterior and lateral portions of the renal fasica from the body wall
renal cortex and renal medulla
What are the two distinct regions of kidney tissue?
renal cortex
the granular and reddish-brown outer layer of the kidney, which is in contact with the renal (or fibrous) capsule
renal columns
Inward extensions of the cortex tissue separating the renal pyramids
renal medulla
darker regions located internal to the renal cortex
consists:
medullary pyramids
renal papillae
renal lobe
renal sinus
large space within the medial part of the kidney opening to the exterior through the renal hilus
renal pelvis
flat, funnel-shaped tube
expanded superior part of the ureter, which has branching extensions of 2-3 major calices
major calices
further branch out as minor calices
minor calices
smaller cup-shaped tubes that enclose the papillae of the pyramids
collect urine draining from the papillae and empty it into the renal pelvis, then into the ureters, and finally into the urinary bladder
function of the calices
Renal A
Segmental A
Lobar A
Interlobar A
Arcuate A
Interlobular A
Afferent Arterioles
Glomerulus
Efferent Arterioles
Peritubular Capillaries/Vasa Recta
Interlobular V
Arcuate V
Interlobar V
Renal V
Inferior Vena Cava
What is the blood flow in the kidneys?
uniferous tubule
the main structural and functional unit of the kidney
nephron
basic functional unit of the kidney
nephron
urine-forming structure
components:
renal corpuscle
proximal convoluted tubule
loop of Henle
distal convoluted tuble
collecting tubule (duct)
concentrates urine by removing water from the urine formed in the nephron
lined by simple epithelium throughout its length
filtration, reabsorption, secretion
What are the 3 mechanisms of urine production?
filtration
filtrate of blood leaves the kidney capillaries and enters the nephron
reabsorption
passive process - most nutrients, water and essential ions are reclaimed from the fitrate and returned to the blood of capillaries
secretion
active process - moves additional undesirable molecules into the collecting tubule from the blood of surrounding capillaries
glomerulus
A ball of capillaries surrounded by Bowman's capsule in the nephron and serving as the site of filtration in the vertebrate kidney.
glomerular capsule
enclosing structure surrounding each glomerulus
afferent and efferent arterioles
The glomerular capillaries are connected to the bloodstream via what two arterioles?
parietal layer
visceral layer (with podocytes and pedicels - foot processes surrounding the glomerular capillaries)
What are the 2 layers of the glomerular capsule?
filtration slits (thin clefts between the pedicels)
filtrate passes into the capsular space through what?
glomerular capillaries
produces FILTRATE that moves through the rest of the uriniferous tubules, forming urine.
filtration membrane or apparatus (barrier)
actual filter that lies between the blood in the glomerulus and the capsular space
1. fenestrated edothelium
2. filtration slits
3. intervening basement membrane
The filtration membrane or apparatus has 3 layers of physical barriers:
mesangial cells
What type of cell is involved with the filtration membrane and functions in:
providing physical support for capillaries
engulf organic materials
regulate the diameters of the glomerular capillaries
proximal convoluted tubule
nephron component that is confined entirely to the renal cortex
- most active in REABSORPTION and SECRETION
- contains increased number of mitochondria
Loop of Henle (nephron loop)
has a descending limb and an ascending loop part of the nephron
thick segment of ascending loop
Loop of Henle
this segment begins in the medulla and contains active transport mechanisms that pump sodium and chloride ions out of the tubular fluid
thin segment of ascending limb
Loop of Henle
this segment is freely permeable to water, but relatively impermeable to ions and other solutes
distal convoluted tubule
confined to the renal cortex
specialized for selective secretion and reabsorption of ions
functions in conserving body fluids
corticol nephrons (85% of all nephrons)
juxtamedullary nephrons (15% of all nephrons)
Classes of nephrons divided according to location
collecting tubules (collecting ducts)
receive urine from distal convoluted tubules
run straight through the cortex into the deep medulla
main function: conserve body fluids
Papillary Ducts (Ducts of Bellini)
The medullary collecting ducts travel to the apex of the pyramid where they merge into larger collecting ducts called ________ that open into the minor calyx.
ADH (antidiuretic hormone)
During water conservation, what hormone is secreted by the posterior pituitary gland and increases permeability of the collecting tubules and DCT to water.
glomerulus: high resistance vessels
peritubular capillaries: drains the cortical glomerulus, low pressure
vasta recta: run alongside loops of henle in deepest part of renal cortex (role: kidney's urine-concentrating mechanism)
Difference between blood vessels associated with the uriniferous tubules:
Glomerulus VS. Peritubular capillaries VS.
vasa recta
the ureters
enters the bladder posteriorly
slender tubes that carry urine from the kidneys to the bladder; continuation of the renal pelvis
mucosa, muscularis, adventitia
What are the 3 basic layers of the ureter walls?
deep to superficial
peristaltic waves
propels urine to bladder
urinary bladder
collaspsible, muscular sac that temporarily stores and expels urine
lies anterior to rectum in males; lies anterior to vagina and inferior to uterus in females
rugae
folds in the mucosal lining disappear as the bladder stretches and fills with urine
posterolateral angles (ureteral openings)
urachus
inferior angle (neck)
trigone
Features of the urinary bladder
trigone
triangular region of the posterior wall of the bladder interior defined by openings for both ureters and the urethra
lacks rugae
smooth and very thick in appearance
acts as a funnel
mucosa, muscularis, fibrous adventitia
What are the 3 layers of the urinary bladder wall from deep to superficial?
detrusor muscle
contraction of this muscle compresses the urinary bladder and expels its contents into the urethra
What kind of muscle is in the muscularis layer of the bladder wall?
prostatic urethra, membranous urethra, spongy urethra
The male urethra is divided into 3 portions.
internal urethral sphincter
thickening of detrusor muscle
INVOLUNTARY sphincter of SMOOTH muscle that keeps the urethra closed when urine is not being passed & prevents dribbling of urine between voidings/urination
external urethral sphincter
surrounds urethra within the sheet of muscle called urogenital diaphragm; SKELETAL muscle
VOLUNTARY sphincter to inhibit urination until proper time
micturition
act of passing urine brought by the contraction of detrusor muscle, assisted by muscles of the abdominal wall, which contract to increase the intra-abdominal pressure
Glomerular (Bowman's) capsule
Proximal convoluted tubule
Loop of Henle
Distal convoluted tubule
Collecting tubule/duct
Papillary duct
Minor calyx
Major calyx
Renal pelvis
Ureter
Urinary Bladder
Urethra
Urine flows through the renal tubule of the kidney in what order?