What is a receptor?
What is another name for ligand gated ion channels?
Intropic receptors
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What is a receptor?
What is another name for ligand gated ion channels?
Intropic receptors
How long does a ligand gated ion channel take to activate?
Milliseconds
What are the key features of a ligand gated ion channel?
What is an example of a ligand gated ion channel?
Nicotinic acetylcholine receptor
How do nicotinic Ach receptors work?
Agonist binds to the receptor causing Na+ ions to move into the cell and become excited, causing depolarisation.
how does the GABAa receptor control Cl- flow?
How does the neuromuscular junction work?
Motor nerves from the spinal cord synapse with skeletal muscle fibres, then each branch forms an end plate region on a motor end plate, initiating contraction.
What are some clinical uses of antagonists?
Tracheal intubation, surgical procedures e.g. abdominal surgery, therapeutic hypothermia.
How can antagonists treat therapeutic hypothermia?
Cardiac arrest, reduce body temp to 32-34 degrees, improves neurological recovery, prevents shivering. Can only be done after anaesthetic as effects whole body.
What is another name for a G-protein coupled receptor?
7 transmembrane receptor or metabotropic receptor
How long does a G-protein coupled receptor take to work?
Seconds
What is a G-protein coupled receptor made up of?
What are key features of G-protein coupled receptors?
What is the basic mechanism of a G-protein coupled receptor?
What are the different Ga subtypes?
GaS (stimulate), Gai (inhibit), GaQ, Ga12
What are effectors?
Ion channels ad enzymes
What are 2nd messengers?
Ions, intracellular
What are some roles of GPCR?
Vascular tone, airway constriction and relaxation, heart contractility, acid secretion, mood, pathogen defense.
How does vascular tone relate to GPCR?