Systems and Synthetic Biology (14)

These flashcards cover essential vocabulary terms and definitions related to Systems and Synthetic Biology, aiding students in exam preparation.

Systems Biology

A field that interprets genomic information in the context of biological pathways, combining -omics data with traditional studies and mathematical modeling.

Synthetic Biology

An engineering discipline that designs and constructs new biological parts, devices, and systems for specific purposes.

Interactome

The term used to describe the interacting components of a cell.

Network Map

A sketch showing interacting proteins, genes, and other molecules involved in biological processes.

Gene Regulatory Networks

Systems that control changes in gene expression in response to environmental changes, consisting of genes, gene products, and their interactions.

Ordinary Differential Equation (ODE)

A mathematical model used to describe the dynamics of gene regulatory networks.

E. coli Gene Count

E. coli has approximately 4,200 genes, including hundreds coding for transcription factors.

Kinetic Theory of Biochemical Reactions

A foundational theory underlying the modeling of gene regulatory networks based on the rates of biochemical reactions.

β

The production rate of protein in gene expression models.

R (Repressor Protein)

A protein that binds to DNA and regulates gene expression by inhibiting transcription.

Kd (Repressor Dissociation Constant)

The concentration of repressor at which gene expression is reduced to half its maximal value.

Growth Rate (𝜆)

A constant representing the rate of exponential microbial growth reliant on the concentration of reactants.

Monod Kinetics

A model describing microbial growth rates as a function of substrate concentration.

COPASI

A biochemical system simulator for modeling and analyzing biochemical networks, capable of performing simulations using differential equations or stochastic kinetics.