cannabis use disorder kroustos

risk of CUD increases with __

earlier age of use, potency, frequency, comorbidities

consequences of CUD

cognitive impairment, poor school/work performance, mood disorders/psychosis

DSM-5 criteria for cannabis use disorder

larger/longer use than intended, unsuccessful effort to cut down, excessive time spent on use, craving, failed responsibilities, continued use despite harm, giving up activities, use in hazardous situations, continued use despite physical/psychological issues, tolerance, withdrawal

mild CUD

2-3 symptoms

moderate CUD

4-5 symptoms

severe CUD

over 6 symptoms

early CUD remission

over 3 months with no criteria besides craving

sustained CUD remission

over 12 months no criteria except craving

acute cannabis intoxication symptoms

euphoria, relaxation, impaired memory, depression, anxiety, hallucinations, paranoia, red eyes, dry mouth, tachycardia, ataxia, speech slurring, chest pain

withdrawal onset

1-2 days

withdrawal peak

2-6 days

withdrawal resolution

3 weeks

withdrawal symptoms

sleep issues, irritability, anxiety, depressed mood, headache, abdominal pain, appetite/weight loss, sweating, chills, tremors

cannabis induced disorders

delirium, psychosis, anxiety disorder, sleep disorder

__ have more potent withdrawal

synthetic canabinoids

cannabinoids are __ that cause downregulation of __

partial CB1/CB2 agonists, CB1

withdrawal of cannabinoids causes a __

hypoactive CB1 state

symptoms of synthetic cannabinoid withdrawal

tachycardia, hypertension, seizures, psychosis

mild withdrawal treatment

exercise, mindfulness, OTC remedies

moderate-severe withdrawal treatment

CBT, symptom based treatment

investigational medications for CUD include

nabiximol, dronabinol

tx for synthetic withdrawal

treat CV and psych symptoms supportively

__ may worsen cannabis withdrawal

nicotine patches

__ improve outcomes

stable employment/school roles

__ is cornerstone of CUD treatment

CBT

nabiximols

CBD/THC spray, decreases withdrawal symptoms

Dronabinol

synthetic THC, decreases withdrawal but no help with abstinence