AntiEpileptics Drugs PHARM SCI/ LAB DRUGS

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What are a group of chronic CNS disorders characterized by recurrent seizures?

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102 Terms

1

What are a group of chronic CNS disorders characterized by recurrent seizures?

Epilepsy, Seizure, Convulsions

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2

rapid firing of neurons when they are not suppose to and a disturbance in the electron channels.

Seizures

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3

1st Generation Antiepileptics

PLEASE CANCEL VOTES PUT EVERYTHING BACK

Phenytoin (Dilantin)

Carbamazepine (Tegretol)

Valproic Acid (Depakote)

Phenobarbital (Luminal)

Ethosuximide (Zarontin)

BZDs

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4

What are the BZD's that are considered 1st Generation Antiepileptics?

COME LOVED DONT COME CRAZY

Clonazepam, Lorazepam, Diazepam, Clorazepate, Clobazam

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5

What generation of anticonvulsants is Felbatol and what is its generic name?

2nd, Felbamate

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6

What generation of anticonvulsantsis Lamotrigine and what is its generic name?

2nd, Lamicital

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7

What generation of anticonvulsants is Gabitril and what is its generic name?

2nd, Tiagabaine

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8

What generation is of anticonvulsants is Sabril and what is its generic name?

2nd, Vigabatrin

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9

What generation of anticonvulsants is Trileptal and what is its generic name?

2nd, Oxcarbazepine

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10

What generation is Vimpat and what is its generic name?

2nd, Lacosamide

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11

What generation of antiepileptics is Lyrica, and what is its generic name?

2nd, Pregabalin

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12

What generation of antiepileptics is Neurontin, and what is its generic name?

2nd, Gabapentin

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13

What generation of antiepileptics is Topamax, and what is its generic name?

2nd, Topiramate

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14

What generation of antiepileptics is Keppra, and what is its generic name?

2nd, Levetiracetam

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15

What generation of antiepiletics is Diastat, and what is its generic name?

2nd, Rectal Diazepam

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16

What generation is Cerebryx and what is its generation?

2nd, Fosphenytoin

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17

WHat generation is Rufinamide and what is its generation?

2ns, Banzel

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18

What are the first generations AEDs that are the first line of therapy in most seizures? PLEASE CANCEL VACATION

Phenytoin, Carbamazepine, Valproic Acid

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19

What drugs is the drug of choice of choice?

Ethosuximide (Zarontin)

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20

What are the 2nd generation drugs used as on add on for?

Children who have refractive seizures

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21

What kind of Agent is Phenytoin?

A sodium channel blocking agent

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22

What kind of agent is Carbamazepine?

A sodium channel blocking agent

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23

What kind of agent is Oxcarbazepine?

A sodium channel blocking agent

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24

What kind of agent is Lamotrigine?

A sodium channel blocking agent

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25

What kind of agent is Topiramate?

A sodium channel blocking agent

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26

What kind of agent is Valporic Acid?

A sodium channel blocking agent

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27

What do BZD's do?

Enhance the action of GABA

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28

What does Tiagabine do?

Inhibits GABA reuptake (used in epilepsy treatment)

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29

What does Vigabatrin do?

Enhance the action of GABA

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30

What does Phenobarbitaul do?

Enhance the action of GABA

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31

What does Primidone do?

Enhance the action of GABA

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32

What does Gabapentin do?

Enhance the action of GABA

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33

What does Pregabalin do?

Enhances the action of GABA

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34

What does Ethosuximide do?

A T- type calcium channel blocker

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35

What does Topiramate do?

Glutamate Receptor Antagonist

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36

What does Felbamate do?

Glutamate Receptor Antagonist

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37

What is the oldest non sedative antiseizure drug

Phenytoin

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38

What has a MOA selective inhibition of sodium channels, prolongs inactive state and Sodium influx is inhibited and AP is suppressed?

Phenytoin

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39

What has a pharmacokinetics of metabolism in the liver, 90% bound plasma proteins?

Phenytoin

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40

What has a therapeutic uses of ALL forms of epilepsy except Abscence seizures due, may worsen?

Phenytoin

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41

What drug has an adverse effect of hyperplasia, hyperglycemia, ataxia, vertigo, anemia, and rash?

Phenytoin

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42

What drug has Tetratogenic effects of fetal hydantoin syndrome (cleft lip, cleft palatat, and cogential heart disease and folate antagonism (birth defects)

Phenytoin

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43

What may epileptic pregnant women have?

increased seizure

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44

What are the drugs that inhibit Phenytoin metabolism?

CDS

Cimetidine, Diazepam, and Sulfonamides

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45

What does Phenytoin do to other drugs with the help of CYP450?

Increase the metabolism of oral contraceptives, cyclosporine, levodopa)

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46

Drugs that induce Phenytoin metabolism does what?

Decrease plasma levels (Carbamazepine, Phenobarbitual)

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47

What drug can cause Gingival Hypertrophy?

Phenytoin- induced

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48

What treats both bipolar disorder and trigeminal neuralgia

Carbamazepine

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49

What has a MOA that blocks sodium channels and inhibits generation of repetitive action potentials?

Carbamazepine

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50

What drug has therapeutic uses of focal seizures and tonic clonic seizures trigeminal neuralgia (worsens absence seizures)

Carbamazepine

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51

What may cause hyponatremia in the elderly?

Carbamazepine

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52

What drug blocks both voltage gated Na+ and T type Ca++ currents?

Zonegran

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53

What enhances GABA receptor function?

Zonegram

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54

What drug may cause kidney stones?

Zonegram

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55

What drug blocks Na+ channels and Ca++ channels and inhibit glutamatw release?

Lamotrigine

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56

What may cause life-threatening rash (SJS) evolving into toxic epidermal necrolysis

Lamotrigine

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57
<p>What picture does this show?</p>

What picture does this show?

SJS

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58

What drug is a glutamate receptor and has a high incidence of fatal aplastic anemia?

Felbatol

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59
<p>What picture does this show?</p>

What picture does this show?

Toxic Epidermal Necrolysis

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60

What inhibits voltage-sensitive sodium and T-type calcium channels, INCREASE GABA synthesis, and DECREASE GABA degradation?

Valproate

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61

What is an alternative to lithium in manic phase of bipolar disordeer?

Valproate

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62

Thromboctopenia

low platelet count

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63

What enhances GABA inhibition used to status epileptics?

Come Love Dont

Clonazepam, Lorazepam, Diazepam

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64

What blocks the reuptake of GABA into neurons used for focal seizures

Tigabine

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65

What drug is a GABA analog (mimics it) that is used for partial seizures in adults and relieves diabetic neuropathy?

Gabapentin

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66

What drug inhibits GABA metabolism by inhibiting GABA and increases the inhibition of GAVA by inhibiting GABA metabolizing enzyme (GABA amino transaminase)?

Vigabintin

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67

What drug blocks T-type calcium channels and is used for absence seizures (particularly in children?

Zarontin

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68

What is used for adults with absence and focal seizures?

Valproate

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69

What is used for absence epilepsy?

Zarontin

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70

What drug inhibits Na+/K+, ATPase, and potentiates GABA activity?

Zarontin

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71

What drug is a glutamate receptor antagonist and has low toxicity but high incidence of fatal aplastic anemia?

Felbatol

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72

What drug is a glutamte receptor and blockss calcium channes, glutamate recetors, augementation of GABA recepor, block the activation of sodium channels, and may cause kidney stones

Topamax

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73

Valproate is used as a drug of choice for what seizures?

Myoclonic, Abscence, Tonic-Clonic, and Atonic seizures

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74

Lamotrigine is used as a drug of choice for what seizures?

Myoclonic and Atonic seizures

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75

Levetirecetam is used as a drug of choice for which seizures?

Tonic clonic, Partial, Myoclonic and Atonic Seizures

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76

Carbamazepine is used as a drug of choice for which seizures?

Partial and Secondarily Generalized Seizures

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77

Oxcarbazepine is used as a drug of choice for which seizures?

Partial and Secondarily Generalized Seizures

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78

Lamotrigine is used for what seizurer?

Partial and Secondarily Generalized Seizures

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79

Ethosuximide is used for what seizures?

Abscence

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80

What drug does the picture show?

Luminal

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81

PHARM SCI LAB STRUCTURES

STAR NECESSARY TERMS IF NEEDED!

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82
<p>What drug does the picture show?</p>

What drug does the picture show?

Mysoline (Primidone)

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83
<p>What drug does this picture show?</p>

What drug does this picture show?

Dilantin (Phenytoin)

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84
<p>What drug does this picture show?</p>

What drug does this picture show?

Cerebyx (Fosphenytoin)

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85
<p>What drug does this picture show?</p>

What drug does this picture show?

Peganone (Ethotoin)

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86
<p>What drug does the picture show?</p>

What drug does the picture show?

Mesantoin (Mephenytoin)

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87
<p>What drug is shown on the picture shown&gt;?</p>

What drug is shown on the picture shown>?

Peganone (Ethotoin)

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88
<p>What drug does this picture show?</p>

What drug does this picture show?

Carbamazepine (Tegretol, Epitol)

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89
<p>What drug does this structure show?</p>

What drug does this structure show?

Oxcarbazepine (Trileptal, Oxtellar XR)

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90

What is the group of oldest and most widely used class of antiepileptic drugs?

Iminostilbenes

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91

What is another name for anticonvulsant drugs?

Hyandtoins

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92

What are the names of the Hydantoins?

Dont Come Making Plays

Dilantin

Cerebryx

Mesantoin

Peganone

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93
<p>What drug does the picture show?</p>

What drug does the picture show?

Lamictal (Lamotrigine)

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94
<p>What drug does this picture show?</p>

What drug does this picture show?

Vimpat (Lacosamide)

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95
<p>What drug does this picture show?</p>

What drug does this picture show?

Zarontin (Ethosuximide)

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96
<p>What drug does this picture show?</p>

What drug does this picture show?

Banzel (Rufinamide)

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97
<p>What drug does this picture show?</p>

What drug does this picture show?

Sodium Valproate

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98

What is Banzel, Dapekene/Depakote classified as?

A Miscellaneous NA Channel Modulator

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99

GABA, Gabepentin, and Pregablin are all considered what?

Voltage Gated Calcium Channel Modulators

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100
<p>What drugs does this picture show?</p>

What drugs does this picture show?

Gabapentin (Neurotin, Gralise, Horizant)

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