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What are a group of chronic CNS disorders characterized by recurrent seizures?
Epilepsy, Seizure, Convulsions
rapid firing of neurons when they are not suppose to and a disturbance in the electron channels.
Seizures
1st Generation Antiepileptics
PLEASE CANCEL VOTES PUT EVERYTHING BACK
Phenytoin (Dilantin)
Carbamazepine (Tegretol)
Valproic Acid (Depakote)
Phenobarbital (Luminal)
Ethosuximide (Zarontin)
BZDs
What are the BZD's that are considered 1st Generation Antiepileptics?
COME LOVED DONT COME CRAZY
Clonazepam, Lorazepam, Diazepam, Clorazepate, Clobazam
What generation of anticonvulsants is Felbatol and what is its generic name?
2nd, Felbamate
What generation of anticonvulsantsis Lamotrigine and what is its generic name?
2nd, Lamicital
What generation of anticonvulsants is Gabitril and what is its generic name?
2nd, Tiagabaine
What generation is of anticonvulsants is Sabril and what is its generic name?
2nd, Vigabatrin
What generation of anticonvulsants is Trileptal and what is its generic name?
2nd, Oxcarbazepine
What generation is Vimpat and what is its generic name?
2nd, Lacosamide
What generation of antiepileptics is Lyrica, and what is its generic name?
2nd, Pregabalin
What generation of antiepileptics is Neurontin, and what is its generic name?
2nd, Gabapentin
What generation of antiepileptics is Topamax, and what is its generic name?
2nd, Topiramate
What generation of antiepileptics is Keppra, and what is its generic name?
2nd, Levetiracetam
What generation of antiepiletics is Diastat, and what is its generic name?
2nd, Rectal Diazepam
What generation is Cerebryx and what is its generation?
2nd, Fosphenytoin
WHat generation is Rufinamide and what is its generation?
2ns, Banzel
What are the first generations AEDs that are the first line of therapy in most seizures? PLEASE CANCEL VACATION
Phenytoin, Carbamazepine, Valproic Acid
What drugs is the drug of choice of choice?
Ethosuximide (Zarontin)
What are the 2nd generation drugs used as on add on for?
Children who have refractive seizures
What kind of Agent is Phenytoin?
A sodium channel blocking agent
What kind of agent is Carbamazepine?
A sodium channel blocking agent
What kind of agent is Oxcarbazepine?
A sodium channel blocking agent
What kind of agent is Lamotrigine?
A sodium channel blocking agent
What kind of agent is Topiramate?
A sodium channel blocking agent
What kind of agent is Valporic Acid?
A sodium channel blocking agent
What do BZD's do?
Enhance the action of GABA
What does Tiagabine do?
Inhibits GABA reuptake (used in epilepsy treatment)
What does Vigabatrin do?
Enhance the action of GABA
What does Phenobarbitaul do?
Enhance the action of GABA
What does Primidone do?
Enhance the action of GABA
What does Gabapentin do?
Enhance the action of GABA
What does Pregabalin do?
Enhances the action of GABA
What does Ethosuximide do?
A T- type calcium channel blocker
What does Topiramate do?
Glutamate Receptor Antagonist
What does Felbamate do?
Glutamate Receptor Antagonist
What is the oldest non sedative antiseizure drug
Phenytoin
What has a MOA selective inhibition of sodium channels, prolongs inactive state and Sodium influx is inhibited and AP is suppressed?
Phenytoin
What has a pharmacokinetics of metabolism in the liver, 90% bound plasma proteins?
Phenytoin
What has a therapeutic uses of ALL forms of epilepsy except Abscence seizures due, may worsen?
Phenytoin
What drug has an adverse effect of hyperplasia, hyperglycemia, ataxia, vertigo, anemia, and rash?
Phenytoin
What drug has Tetratogenic effects of fetal hydantoin syndrome (cleft lip, cleft palatat, and cogential heart disease and folate antagonism (birth defects)
Phenytoin
What may epileptic pregnant women have?
increased seizure
What are the drugs that inhibit Phenytoin metabolism?
CDS
Cimetidine, Diazepam, and Sulfonamides
What does Phenytoin do to other drugs with the help of CYP450?
Increase the metabolism of oral contraceptives, cyclosporine, levodopa)
Drugs that induce Phenytoin metabolism does what?
Decrease plasma levels (Carbamazepine, Phenobarbitual)
What drug can cause Gingival Hypertrophy?
Phenytoin- induced
What treats both bipolar disorder and trigeminal neuralgia
Carbamazepine
What has a MOA that blocks sodium channels and inhibits generation of repetitive action potentials?
Carbamazepine
What drug has therapeutic uses of focal seizures and tonic clonic seizures trigeminal neuralgia (worsens absence seizures)
Carbamazepine
What may cause hyponatremia in the elderly?
Carbamazepine
What drug blocks both voltage gated Na+ and T type Ca++ currents?
Zonegran
What enhances GABA receptor function?
Zonegram
What drug may cause kidney stones?
Zonegram
What drug blocks Na+ channels and Ca++ channels and inhibit glutamatw release?
Lamotrigine
What may cause life-threatening rash (SJS) evolving into toxic epidermal necrolysis
Lamotrigine
What picture does this show?
SJS
What drug is a glutamate receptor and has a high incidence of fatal aplastic anemia?
Felbatol
What picture does this show?
Toxic Epidermal Necrolysis
What inhibits voltage-sensitive sodium and T-type calcium channels, INCREASE GABA synthesis, and DECREASE GABA degradation?
Valproate
What is an alternative to lithium in manic phase of bipolar disordeer?
Valproate
Thromboctopenia
low platelet count
What enhances GABA inhibition used to status epileptics?
Come Love Dont
Clonazepam, Lorazepam, Diazepam
What blocks the reuptake of GABA into neurons used for focal seizures
Tigabine
What drug is a GABA analog (mimics it) that is used for partial seizures in adults and relieves diabetic neuropathy?
Gabapentin
What drug inhibits GABA metabolism by inhibiting GABA and increases the inhibition of GAVA by inhibiting GABA metabolizing enzyme (GABA amino transaminase)?
Vigabintin
What drug blocks T-type calcium channels and is used for absence seizures (particularly in children?
Zarontin
What is used for adults with absence and focal seizures?
Valproate
What is used for absence epilepsy?
Zarontin
What drug inhibits Na+/K+, ATPase, and potentiates GABA activity?
Zarontin
What drug is a glutamate receptor antagonist and has low toxicity but high incidence of fatal aplastic anemia?
Felbatol
What drug is a glutamte receptor and blockss calcium channes, glutamate recetors, augementation of GABA recepor, block the activation of sodium channels, and may cause kidney stones
Topamax
Valproate is used as a drug of choice for what seizures?
Myoclonic, Abscence, Tonic-Clonic, and Atonic seizures
Lamotrigine is used as a drug of choice for what seizures?
Myoclonic and Atonic seizures
Levetirecetam is used as a drug of choice for which seizures?
Tonic clonic, Partial, Myoclonic and Atonic Seizures
Carbamazepine is used as a drug of choice for which seizures?
Partial and Secondarily Generalized Seizures
Oxcarbazepine is used as a drug of choice for which seizures?
Partial and Secondarily Generalized Seizures
Lamotrigine is used for what seizurer?
Partial and Secondarily Generalized Seizures
Ethosuximide is used for what seizures?
Abscence
What drug does the picture show?
Luminal
PHARM SCI LAB STRUCTURES
STAR NECESSARY TERMS IF NEEDED!
What drug does the picture show?
Mysoline (Primidone)
What drug does this picture show?
Dilantin (Phenytoin)
What drug does this picture show?
Cerebyx (Fosphenytoin)
What drug does this picture show?
Peganone (Ethotoin)
What drug does the picture show?
Mesantoin (Mephenytoin)
What drug is shown on the picture shown>?
Peganone (Ethotoin)
What drug does this picture show?
Carbamazepine (Tegretol, Epitol)
What drug does this structure show?
Oxcarbazepine (Trileptal, Oxtellar XR)
What is the group of oldest and most widely used class of antiepileptic drugs?
Iminostilbenes
What is another name for anticonvulsant drugs?
Hyandtoins
What are the names of the Hydantoins?
Dont Come Making Plays
Dilantin
Cerebryx
Mesantoin
Peganone
What drug does the picture show?
Lamictal (Lamotrigine)
What drug does this picture show?
Vimpat (Lacosamide)
What drug does this picture show?
Zarontin (Ethosuximide)
What drug does this picture show?
Banzel (Rufinamide)
What drug does this picture show?
Sodium Valproate
What is Banzel, Dapekene/Depakote classified as?
A Miscellaneous NA Channel Modulator
GABA, Gabepentin, and Pregablin are all considered what?
Voltage Gated Calcium Channel Modulators
What drugs does this picture show?
Gabapentin (Neurotin, Gralise, Horizant)
Note 
Flashcard (20)