AntiEpileptics Drugs PHARM SCI/ LAB DRUGS

What are a group of chronic CNS disorders characterized by recurrent seizures?

Epilepsy, Seizure, Convulsions

rapid firing of neurons when they are not suppose to and a disturbance in the electron channels.

Seizures

1st Generation Antiepileptics

PLEASE CANCEL VOTES PUT EVERYTHING BACK

Phenytoin (Dilantin)

Carbamazepine (Tegretol)

Valproic Acid (Depakote)

Phenobarbital (Luminal)

Ethosuximide (Zarontin)

BZDs

What are the BZD's that are considered 1st Generation Antiepileptics?

COME LOVED DONT COME CRAZY

Clonazepam, Lorazepam, Diazepam, Clorazepate, Clobazam

What generation of anticonvulsants is Felbatol and what is its generic name?

2nd, Felbamate

What generation of anticonvulsantsis Lamotrigine and what is its generic name?

2nd, Lamicital

What generation of anticonvulsants is Gabitril and what is its generic name?

2nd, Tiagabaine

What generation is of anticonvulsants is Sabril and what is its generic name?

2nd, Vigabatrin

What generation of anticonvulsants is Trileptal and what is its generic name?

2nd, Oxcarbazepine

What generation is Vimpat and what is its generic name?

2nd, Lacosamide

What generation of antiepileptics is Lyrica, and what is its generic name?

2nd, Pregabalin

What generation of antiepileptics is Neurontin, and what is its generic name?

2nd, Gabapentin

What generation of antiepileptics is Topamax, and what is its generic name?

2nd, Topiramate

What generation of antiepileptics is Keppra, and what is its generic name?

2nd, Levetiracetam

What generation of antiepiletics is Diastat, and what is its generic name?

2nd, Rectal Diazepam

What generation is Cerebryx and what is its generation?

2nd, Fosphenytoin

WHat generation is Rufinamide and what is its generation?

2ns, Banzel

What are the first generations AEDs that are the first line of therapy in most seizures? PLEASE CANCEL VACATION

Phenytoin, Carbamazepine, Valproic Acid

What drugs is the drug of choice of choice?

Ethosuximide (Zarontin)

What are the 2nd generation drugs used as on add on for?

Children who have refractive seizures

What kind of Agent is Phenytoin?

A sodium channel blocking agent

What kind of agent is Carbamazepine?

A sodium channel blocking agent

What kind of agent is Oxcarbazepine?

A sodium channel blocking agent

What kind of agent is Lamotrigine?

A sodium channel blocking agent

What kind of agent is Topiramate?

A sodium channel blocking agent

What kind of agent is Valporic Acid?

A sodium channel blocking agent

What do BZD's do?

Enhance the action of GABA

What does Tiagabine do?

Inhibits GABA reuptake (used in epilepsy treatment)

What does Vigabatrin do?

Enhance the action of GABA

What does Phenobarbitaul do?

Enhance the action of GABA

What does Primidone do?

Enhance the action of GABA

What does Gabapentin do?

Enhance the action of GABA

What does Pregabalin do?

Enhances the action of GABA

What does Ethosuximide do?

A T- type calcium channel blocker

What does Topiramate do?

Glutamate Receptor Antagonist

What does Felbamate do?

Glutamate Receptor Antagonist

What is the oldest non sedative antiseizure drug

Phenytoin

What has a MOA selective inhibition of sodium channels, prolongs inactive state and Sodium influx is inhibited and AP is suppressed?

Phenytoin

What has a pharmacokinetics of metabolism in the liver, 90% bound plasma proteins?

Phenytoin

What has a therapeutic uses of ALL forms of epilepsy except Abscence seizures due, may worsen?

Phenytoin

What drug has an adverse effect of hyperplasia, hyperglycemia, ataxia, vertigo, anemia, and rash?

Phenytoin

What drug has Tetratogenic effects of fetal hydantoin syndrome (cleft lip, cleft palatat, and cogential heart disease and folate antagonism (birth defects)

Phenytoin

What may epileptic pregnant women have?

increased seizure

What are the drugs that inhibit Phenytoin metabolism?

CDS

Cimetidine, Diazepam, and Sulfonamides

What does Phenytoin do to other drugs with the help of CYP450?

Increase the metabolism of oral contraceptives, cyclosporine, levodopa)

Drugs that induce Phenytoin metabolism does what?

Decrease plasma levels (Carbamazepine, Phenobarbitual)

What drug can cause Gingival Hypertrophy?

Phenytoin- induced

What treats both bipolar disorder and trigeminal neuralgia

Carbamazepine

What has a MOA that blocks sodium channels and inhibits generation of repetitive action potentials?

Carbamazepine

What drug has therapeutic uses of focal seizures and tonic clonic seizures trigeminal neuralgia (worsens absence seizures)

Carbamazepine

What may cause hyponatremia in the elderly?

Carbamazepine

What drug blocks both voltage gated Na+ and T type Ca++ currents?

Zonegran

What enhances GABA receptor function?

Zonegram

What drug may cause kidney stones?

Zonegram

What drug blocks Na+ channels and Ca++ channels and inhibit glutamatw release?

Lamotrigine

What may cause life-threatening rash (SJS) evolving into toxic epidermal necrolysis

Lamotrigine

What picture does this show?

SJS

What drug is a glutamate receptor and has a high incidence of fatal aplastic anemia?

Felbatol

What picture does this show?

Toxic Epidermal Necrolysis

What inhibits voltage-sensitive sodium and T-type calcium channels, INCREASE GABA synthesis, and DECREASE GABA degradation?

Valproate

What is an alternative to lithium in manic phase of bipolar disordeer?

Valproate

Thromboctopenia

low platelet count

What enhances GABA inhibition used to status epileptics?

Come Love Dont

Clonazepam, Lorazepam, Diazepam

What blocks the reuptake of GABA into neurons used for focal seizures

Tigabine

What drug is a GABA analog (mimics it) that is used for partial seizures in adults and relieves diabetic neuropathy?

Gabapentin

What drug inhibits GABA metabolism by inhibiting GABA and increases the inhibition of GAVA by inhibiting GABA metabolizing enzyme (GABA amino transaminase)?

Vigabintin

What drug blocks T-type calcium channels and is used for absence seizures (particularly in children?

Zarontin

What is used for adults with absence and focal seizures?

Valproate

What is used for absence epilepsy?

Zarontin

What drug inhibits Na+/K+, ATPase, and potentiates GABA activity?

Zarontin

What drug is a glutamate receptor antagonist and has low toxicity but high incidence of fatal aplastic anemia?

Felbatol

What drug is a glutamte receptor and blockss calcium channes, glutamate recetors, augementation of GABA recepor, block the activation of sodium channels, and may cause kidney stones

Topamax

Valproate is used as a drug of choice for what seizures?

Myoclonic, Abscence, Tonic-Clonic, and Atonic seizures

Lamotrigine is used as a drug of choice for what seizures?

Myoclonic and Atonic seizures

Levetirecetam is used as a drug of choice for which seizures?

Tonic clonic, Partial, Myoclonic and Atonic Seizures

Carbamazepine is used as a drug of choice for which seizures?

Partial and Secondarily Generalized Seizures

Oxcarbazepine is used as a drug of choice for which seizures?

Partial and Secondarily Generalized Seizures

Lamotrigine is used for what seizurer?

Partial and Secondarily Generalized Seizures

Ethosuximide is used for what seizures?

Abscence

What drug does the picture show?

Luminal

PHARM SCI LAB STRUCTURES

STAR NECESSARY TERMS IF NEEDED!

What drug does the picture show?

Mysoline (Primidone)

What drug does this picture show?

Dilantin (Phenytoin)

What drug does this picture show?

Cerebyx (Fosphenytoin)

What drug does this picture show?

Peganone (Ethotoin)

What drug does the picture show?

Mesantoin (Mephenytoin)

What drug is shown on the picture shown>?

Peganone (Ethotoin)

What drug does this picture show?

Carbamazepine (Tegretol, Epitol)

What drug does this structure show?

Oxcarbazepine (Trileptal, Oxtellar XR)

What is the group of oldest and most widely used class of antiepileptic drugs?

Iminostilbenes

What is another name for anticonvulsant drugs?

Hyandtoins

What are the names of the Hydantoins?

Dont Come Making Plays

Dilantin

Cerebryx

Mesantoin

Peganone

What drug does the picture show?

Lamictal (Lamotrigine)

What drug does this picture show?

Vimpat (Lacosamide)

What drug does this picture show?

Zarontin (Ethosuximide)

What drug does this picture show?

Banzel (Rufinamide)

What drug does this picture show?

Sodium Valproate

What is Banzel, Dapekene/Depakote classified as?

A Miscellaneous NA Channel Modulator

GABA, Gabepentin, and Pregablin are all considered what?

Voltage Gated Calcium Channel Modulators

What drugs does this picture show?

Gabapentin (Neurotin, Gralise, Horizant)