Coag Final Review

Which of the following initiates the coagulation cascade IN VIVO?

tissue factor

Which test evaluates the extrinsic pathway?

PT (INR)

The anticoagulant of choice for most routine coagulation studies is

sodium citrate

The intrinsic and extrinsic pathways "meet" at the common pathway with the activation of which factor?

X

Activated factor X converts prothrombin to

thrombin

_______________ converts fibrinogen to fibrin.

thrombin

Following damage to a blood vessel theimmediate reaction of the vessel is

vasoconstriction

A unique characteristic of a platelet is

anuclear

Which blood vessels have the thickest walls?

arteries

Vasoconstriction can last for up to

30 minutes

The difference between petechiae and purpura is that petechiae appear as

hemorrhagic spots on the skin or mucous membranes

A deficiency of Vitamin K will not affect a patient’s clotting ability

false

DIC stands for

disseminated intravascular coagulation

Antiphospholipid Syndrome (APS) is mainlyassociated with ___________ in women

recurrent miscarriage

Christmas disease is also known as

Hemophilia B

Factor IX and _______ deficiencies are x-linked disorders of secondary hemostasis

VIII

Which test measures how long a plasma sample takes to clot after a mixture of thromboplastin and calcium are added?

Protime (Prothrombin Time, PT)

Name one condition D-Dimer is used to help diagnose. (all of these)

-DIC

-PE

-DVT

Thrombopoietin is thought to stimulate the production and maturation of megakaryocytes

true

von Willebrand’s factor is also called _________

VIII:C

Aspirin blocks _____________

Platelet aggregation

Hemophilia A (Classic Hemophilia) is more common in females than males

false

Hemophilia C is a deficiency of Factor XI which has an important role in the coagulation cascade. Factor XI is critical for the production of ____________ which converts fibrinogen to fibrin, which holds the clot in place.

thrombin

Coagulation testing is dependent on the quality of the specimen

true

Which test measures the integrity of the platelet plug?

bleeding time

Substitution studies (mixing studies) are used to __________

Identify factor deficiencies

Wafarin is ________________

Similar to coumadin

What does INR stand for?

International normalized ratio

Afibrinogenemia is a deficiency of Factor

I

AT III is the principal physiological inhibitor of

thrombin

An example of a hereditary platelet adhesion defect is

Bernard-Soulier syndrome

Factor I

fibrinogen

Factor II

Prothrombin

Factor V

Proaccelerin

Factor VIII

Anti-hemophiliac factor

Factor X

Stuart factor

Factor XII

Hageman factor

The increase in the likelihood of blood to clot is referred to as the hypocoagulable state

false

This test is good to measure the ability of VWF to support agglutination of normal platelets by ristocetin

Platelet aggregation studies

Antihemophiliac factor is which coagulation factor?

Factor VIII

The sequence of events following an injury to a small blood vessel is (in order)

o   1) blood vessel spasm (vasoconstriction)

o   2) formation of a platelet plug

o   3) contact between damaged blood vessels, blood platelets, and coagulation proteins

o   4) development of a blood clot around the injury

o   5) fibrinolysis and reestablishment of vascular integrity

Which of the following is true?

The extrinsic system is activated first, and then the intrinsic system is turned on later

What goes is blank A in the coagulation cascade pictured below?

XII

What goes in blank B in the coagulation cascade pictured below?

X

What goes in blank C in the coagulation cascade pictured below?

fibrinogen

The function of factor XIII is

to stabilize the clot