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Introduction, Macroanatomy of Skeletal Muscle, Microstructure of Skeletal Muscle
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Excitability
Receives and responds to stimuli; one of the characteristics of muscle tissue
Contractibility
Can shorten when stimulated; one of the characteristics of muscle tissue
Extensibility
Can stretch when pulled; one of the characteristics of muscle tissue
Elasticity
Can return to its original shape after contraction or extension; one of the characteristics of muscle tissue
Skeletal (striated)
a type of muscle tissue that is under voluntary control; attached to bones
Visceral (smooth)
a type of muscle tissue that is involuntary; responsible for the movements of the internal organs
Cardiac
a type of muscle tissue that is striated and involuntary; causes the heartbeat and is self-generating (myogenic)
Muscle fibers (cells)
Organized into functional units called muscles
Fascia
A thin sheet of fibrous connective tissue that surrounds each skeletal muscle and cell; reinforces the muscle, provides a passageway for nerves and blood vessels, and participates in muscle attachment
Epimysium
a sheet of dense irregular tissue that surrounds the entire muscle
Perimysium
An inward fold of epimysium surrounding a fasciculus (bundle of muscle fibers); there are many
Endomysium
An inward fold of perimysium around a single muscle fiber, but separated from the cell membrane by an interstitial space
Direct attachment
Epimysium connects directly to the periosteum of the bone
Indirect attachment
Extensions of the perimysium from tendons and aponeurosis that anchor the muscle to bone, fascia, or cartilage of other bones
Series-elastic component
The various connective tissue elements; not excitable of contractile, but it is extensible and elasticInte
Internal tension
The force muscle creates first when contracting, stretching the series-elastic components
External tension
Once fully contracted, continued shortening of the muscle exerts this force; causes its eventual movement
Sarcolemma
The muscle fiber membrane; it maintains cell potential and receives the contraction signal
Sarcoplasm
The cytoplasm of the muscle fiber
Sarcoplasmic reticulum
A modified ER, primarily involved with calcium storage and release during the contraction cycle
Terminal cisternae
Enlargements of the SR where most of the calcium is stored
Transverse (T) tubules
A deep protrusion of the sarcolemma that forms a penetrating tubular system; the lumen contains extracellular fluid
Triad
The association of terminal cisternae and a T-tubule; demarks the beginning and ending of each sarcomere
Myofibrils
Hundreds or thousands of these that make up a muscle fiber
Myofilaments
Protein filaments that also make up myofibril
Thin filaments
Composed primarily of fibrous (F) action which in turn is formed from multiple globular (G) actin molecules end to end
Thick filaments
Constructed primarily of myosin which can interact with attachment sites on each G actin
Troponin
The site where calcium ions bond; contributes to muscle contraction
Tropomyosin
Covers the actin active sites preventing cross-bridge formation with the myosin heads; contributes to muscle contraction
Striations
The spatial arrangement of various elements producing shading patterns
Sarcomeres
Functional units in which myofilaments are organized; they are stacked end to end in the cell
Z disc
The ends of the sarcomere; a protein structure connected to the thin (actin) filaments directly and indirectly to the thick (myosin) filament via the elastic filament
Motor neurons
Supply the neural stimulation needed to initiate contraction
Neuromuscular junction
A specialized junction formed between the neuron and the skeletal muscle cell
Synaptic cleft
The small interstitial space between the ending of the motor neuron and the cell membrane
Motor unit
Made up of fibers (~150) controlled by one neuron; contract simultaneously