Population Genetics Synthesis: Integrates Mendelian inheritance with Darwinian evolution.
Combines natural selection with genetic principles.
Focuses on microevolution (changes in allele frequencies) and its link to macroevolution (speciation).
Modern Synthesis:
Microevolution: Small changes in allele frequencies within a population.
Macroevolution: Large-scale changes leading to new species or taxonomic groups.
Hardy-Weinberg Principle:
Describes non-evolving populations: allele frequencies remain constant if five conditions are met:
No mutations.
Random mating.
No natural selection.
Extremely large population size (no genetic drift).
No gene flow (immigration/emigration).
Equation: p² + 2pq + q² = 1, where:
p = dominant allele frequency.
q = recessive allele frequency.
Deviations from equilibrium indicate evolution (e.g., pesticide resistance in mosquitoes).
Natural Selection: Favors advantageous alleles, increasing their frequency.
Genetic Drift:
Random changes in allele frequencies, especially in small populations.
Examples: Founder Effect (small group isolation) and Bottleneck Effect (population reduction).
Gene Flow: Movement of alleles between populations.
Mutation: Source of new genetic variation.
Sources of Variation:
Polymorphisms: Different alleles lead to varied traits (e.g., blood types).
Environmental Influence: Traits like alligator sex determination depend on incubation temperature.
Heritable vs. Non-Heritable Traits:
Only genetic traits are subject to evolution.
Natural Selection: Acts on phenotypes to favor beneficial traits.
Genetic Drift:
Bottleneck Effect: Random reduction in population size.
Founder Effect: Isolated populations develop unique allele frequencies.
Gene Flow: Introduction or removal of alleles due to migration.
Non-Random Mating: Influences genotype frequencies (e.g., assortative mating).
Predict allele frequencies using the equation.
Deviations reveal selective pressures or other evolutionary forces.
Stabilizing Selection: Favors average phenotypes (e.g., mouse coat matching forest floor).
Directional Selection: Favors one extreme phenotype (e.g., darker moths during industrialization).
Diversifying Selection: Favors extreme phenotypes (e.g., light and dark mice in variable habitats).
Frequency-Dependent Selection:
Positive: Favors common traits.
Negative: Favors rare traits.
Sexual Selection:
Leads to sexual dimorphism (e.g., peacock tails).
Handicap Principle: Traits signaling high fitness despite survival costs.
Acts only on existing variation; cannot create new traits.
Linked genes and trade-offs can constrain adaptation.