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What are the different designs of bioreactors?
Commercial Lab-scale CSTRs
control tower
reactor and everything on balances
How to select a reactor type?
oxygen
density
Basic considerations in bioreactior and bioprocess design
What is the product?
How much does the product cost?
What is the production cost?
Factors contributing to the production costs
R&D
reactor building
raw materials and media
upstream operation (labor, energy, water, waste disposal, depreciation insurance) 20%
downstram processing 70-80%
…
baffles
min. 4 vertical bars near walls of reactor to create turbulent flow to aid with mixing
Why is mixing needed?
Which geometry is best for a CSTR mixing?
The different patterns of gas ditribution, and the best one
impeller flooding
impeller loading
complete gas dispersion
too fast an impeller speed can break cells
Power number
Reynold’s number