Immunology Final (copy)

what is an example of an intracellular DAMP

HMGB1

which IL is responsible for the response against parasites

IL-5

what TF is used to produce Th17

ROR gamma

what does MHC I do

gives endogenous peptides to C8

what is needed to initiate phagocytosis

opsonin

what do selectin and integrin do

assist with adhesion of neutrophils

what do PAMP and DAMP initiate

innate defense

what immunity has memory and ?

adaptive

which pathway uses adaptive immunity

classical

what will start the classical pathway

2 IgG molecules

what is an example of a sentinel cell

mast cell

what is it called when cells are signaled to go to a site

chemotaxis

what are the main cytokines that create Th1

IL-2 and IFN gamma

humoral immunity involves

antibodies

what leukocyte is the first responders and is 55-90% of blood

neutrophils

what is the primary lymphoid tissue for ruminants, pigs, and dogs

peyers patch

which APC is 100x more effective

dendritic cell

what TLRs are not working correctly in IBD for German Sheperds

TBL 4 and 5

which cardinal signal occurs from irritation of sensory nerve receptors

pain

what is the disease where Holstein calves have a point mutation in integrin gene

bovine leukocyte adhesion deficiency

what is a cytotoxic mediator

C5a

what is the best antigen

protein

what is a carrier

protein attached to a small molecule

plastics and stainless steel are

not digestable

what cell has immune complexes that form iccosomes

follicular dendrites

what cells have MHC II present

B cell, dendritic, macrophages

what is it called when T cell recognizes self during MHC maturation

positive selection

what do dendritic cells do

present MHC to T cells

what inhibits Th1

IL-10

NKG2D is a receptor for what cells

NK cells

what does it mean when a cytokine acts on cell that produced it

autocrine

what 2 things can't be on same MHC

CD4 and CD8

what is the function of APCs

present antigen to MHC

what IL is responsible for lymphocyte proliferation

IL-2

what are examples of lymphocytes

B cells, T cells, NK cells

what is CD79

B cell signal transducing component

in primary immune response

IgM> IgG

what does Fc region contain

Ch2 and beyond

which of the following is not in immunoglobulin light chain

D gene

what Ig is pentameric and found in blood stream

IgM

what Ig will help with response to allergies

IgE

what Ig is used in secondary innate response

IgG

what type of placenta will do placental transfer of Ab

hemochorial

what is the processes when a single gene is selected at random and joined with other

gene recombination

what will facilitate cell suicide

caspase

what process has hallmark membrane blebbing and DNA fragmentation

apoptosis

what type of virus has the greatest chance of antigenic variation

RNA

what process will CD95 initiate apoptosis of

self T cells

how does T gondii evade immune system

goes into macrophage to reproduce

what mutation is seen in dogs with AD

TLR 2

what dos tick saliva have that allows host to not recognize it

antihistamine and vasodilator

sheep resistant to Haemanthus have

MHC linked genes

what will inhibit protein synthesis and viral translation

elf2A

what happens in successful inflammatory response

IL-23 activates Th17

what pathway is evaded by factor H binding

alternative

what is the most important receptor for fetal Ab uptake

intestinal Fc

what is true of fetal/mother response so that inflammatory response is downregulated

Th2 response from fetus

in Johne's disease what accounts for over activation of immune system

increased Th2 response

what is unresponsiveness of immune system to antigens

tolerance

what will express CD25 while immature

Treg

what are the immunosuppressive cytokines that inhibit Th1

IL-10, IL-35, TGF beta

where is the site where antigens can be brought in

inductive site

how does S. aureus inhibit phagocytosis

binds to Fc

if animal has lack of gut microbiota, what should you do

feed intestinal tracts ?

what is the phenomenon in which adaptive response that has potential to cause indirect tissue damage is converted to less harmful response

immune deviation

what is the most common in dogs

idiopathic non erosive arthritis

foal gets sick 6 hours after eating, what is happening

FPT

which of the following is an advantage of infectious vaccine

no adjuvant

how does tumor cell evade host immune system

downregulate MHC I

what animal has preformed antibodies

cat

what is the most immunologic blood type in dogs

DEA 1.1

what hypersensitivity occurs when mast cells are downregulated

type I

what is the shock organ in a dog

liver

what type of hypersensitivity is shown here (blue eye pic)

type III

what cannot be cleared in SLE

nuclear fragments

what cell is affected in Chediak higashi syndrome

neutrophil

what is being detected in snap test for FIV

antibody against infection

what does cyclosporine inhibit

calcineurin

what inhibits IMPDH

mycophenolate

what test would be used to determine the number of a particular cell

flow cytometry

what is true about titers

can be used to screen for vaccination response

what is enzyme is needed to make melanocytes

tyrosinase

what causes clonal deletion

fasL/fas

what does FELV test for

p27

what is a antimetabolic

azathioprine

what is an example of a defect in mechanical barrier

ciliary dyskenia

PDL1 inhibition helps

T cell see tumor

bee sting would be what type of hypersensitivity

type I

blood transfusion reaction is an example of what type of hypersensitivity

type II

A newborn foal develops jaundice, weakness, and anemia within 36 hours of birth. Laboratory tests reveal the presence of antibodies bound to the foal's red blood cells, leading to their destruction. Which type of hypersensitivity reaction is most consistent with this condition?

type II