cell adhesion & junctional complexes (S.P)

what are the two types of extracellular matrices

basal laminar matrix and fibrillar matrix

where is the basal lamina found commonly?

underneath/underlying epithelial cells

is basal lamina 2D or 3D

2d

is fribrillar matrix 2D or 3D

3D

what is the fibrillar matrix made of?

fibroblasts and proteins

what type of collagen is basal lamina made of (1 or 4)

4

what type of collagen is fibrillar matrix made of (1 or 4)

1

what are the 6 types of junctional complexes in cells

1. tight junction

2. adherens junctions

3. desmosomes

4. hemidesmosomes

5. gap junctions

6. focal adhesions

where are desmosomes and hemidesmosomes found

at cell-cell contact

what do desmosomes and hemidesmosomes look like under elec microscope

desmosomes are pairs dark discs structures. hemidesmosomes is the same but half a desmosomes (half a disk)

what relationship do desmo./hemidesmo. have with intermediate filaments

desmo/hemidesmo are attached intracellullarly to IF

what function does intermediate filaments have in epithelial cells for example

support against mechanical stress (allows the cells to stretch

what can mutations in the desmosomes lead to

skin diseases due to low keratin 

where are tight junctions found in the cell 

they form a ring in the apical surface

what is the function of the tight junction

to prevent the passage of molecules like fluids and substrates

what are tight junctions made of

claudin and occludin (occludin = occlude = block)

what do gap junctions allow the movement of

ions and molecules

how do ion and molecules move across cells and why s it important to the cell

via fenestrations (pore) and its important because it allows the maintenance of potential differences within the cell

what are the adherin junctions coupled (linked) to

actin cytoskeleton

what does the coupling of adherin allow to happen

allows contractile force to occur and sheet of cells change shape and become round

in adherins junction section, what is CA2+ ion dependent

the homophilic (same) binding od E-Cadherins

what does focal adhesion link together?

the actin cytoskeleton to the extracellular matrix (ECM) via intergrins [focal adhesion acts as a cell matrix anchoring junction whatever that means maybe like it anchors or keeps the matrix in a certain place

what are cadherins?

Ca2+ ion adhesion molecules [cadherin is literally short for calcium adhesion]

what is cancer metastasis and how does it relate to this topic?(bad q sorry)

spread of cancer via blood from site A to site B. related to topic because the metastasis of cancer may be linked to cell adhesion as cells are packed closely together and loss/changes in cadherins can cause cancers to spread (maybe idk)