advanced pharmacolog (march 28 notes part 2)

bile acid sequestrants are made from

cholesterol

bile acid sequestrant function

hug/hang onto cholesterol

bile acid sequestrants MOA

bind to bile acids in the small intestine to prevent absorption

bile acid sequestrant indication

give with statin for additive effect or alone if liver/kidney disease

bile acid sequestrant contraindications

biliary or bowel obstruction

bile acid sequestrants SE

constipation, gas, heartburn, nausea

when to take other meds with bile acid sequestrants

1 hour before or 4-6 hours after

bile acid sequestrants cause decreased absorption of

fat-soluble vitamins

bile acid sequestrant drugs

cholestyramine (questran) and colesevelam (WelChol)

niacin

nicotinic acid

niacin

vitamin B3 (higher doses)

niacin is good because

effective, inexpensive, often used in combo drugs

niacin MOA

increases activity of lipase, inhibits lipolysis in adipose tissue

niacin SE

flushing, pruritus, GI distress

niacin SE prevention

low initial dose, take with meals, take NSAID 30 minutes before dose

fibric acid derivatives (fibrates) MOA

activates lipoprotein lipase, suppresses free fatty acid release from adipose, inhibits synthesis of triglycerides in liver, increases secretion of cholesterol in bile

fibric acid derivatives (fibrates) SE

GI, GU, prolonged PT, increased LFT