Biol 266 Kahoot: Protein Trafficking

Which of the following is the correct order of locations for the travel of a newly synthesized plasma membrane protein?

Lysosome -> endosome -> plasma membrane

ER -> endosome -> plasma membrane

Golgi -> lysosome -> plasma membrane

ER -> Golgi -> plasma membrane

ER -> Golgi -> plasma membrane

Molecules to be packaged into vesicles for transport are selected by:

Clathrin

Adaptor proteins

SNAREs

Rab GTPases

Adaptor proteins

How are COP coats removed from vesicles?

The vesicle changes its lipid composition.

GEFs in the vesicle activate the GTPases which removes the coat proteins.

GAPs in the vesicle inactivate the GTPases which removes the coat proteins.

COP proteins are phosphorylated which removes them from the vesicle.

GAPs in the vesicle inactivate the GTPases which removes the coat proteins.

An individual transport vesicle:

Contains only one type of protein in its lumen.

Will fuse with only one type of target membrane.

Is endocytic if it is traveling toward the plasma membrane.

Contains the same membrane protein composition as its source organelle

Will fuse with only one type of target membrane.

How many of the following proteins bind improperly folded proteins in the ER?

Calreticulin

Calnexin

Hsp70

RabGTPases

t-SNARE

Clathrin

Calreticulin

Calnexin

Hsp70

The cell decides to dislocate a protein from the ER to the cytoplasm to be degraded. At this stage, this protein has:

Glc1Man9(GlcNAc)2

Glc2Man9(GlcNAc)2

Man9(GlcNAc)2

Man5(GlcNAc)2

Man5(GlcNAc)2

What is one of the goals of the unfolded protein response?

Increase translation of ER proteins.

Inhibit the translation of chaperone proteins.

Increase the size of the ER.

Increase the size of the Golgi.

Increase the size of the ER.

Where would you expect to find disulfide bonds?

The cytoplasmic domain of a channel protein.

The extracellular domain of a channel protein.

A mitochondrial protein.

The lumenal domain of a lysosomal membrane protein.

The extracellular domain of a channel protein.

The lumenal domain of a lysosomal membrane protein.

What vesicle coat will you find on vesicles traveling from the plasma membrane to the endosome?

Clathrin

COPI

COPII

SNARE

Clathrin

Which GTPase mediates the formation of COPII coats?

ARF

Sar1

Rab5

Ran

Sar1