Biochem Chapter 39 Neurochemistry

Demyelination of CNS is _____ _____

Demyelination of PNS is _____ _____

Multiple sclerosis

Guillain-Barre

Asialotransferrin is a protein found in CSF. Is it normal to find in nasal discharge?

No and it should be repaired or it will cause meningitis

Campylobacter jejuni contain antigen shared with ______ ______.

Can cause ______ ______

peripheral nerves

Guillain-Barre

Neurons stop dividing ______

postpartum

________ is responsible for anterograde

________ is responsible for retrograde

Kinesin

Dynein

A relatively stable high rate of glucose provision is secured by the high-affinity transporter GLUT____, expressed only in neurons.

3

When there is injury to the CNS, ______ can play a major part in the reaction, synthesizing large amounts of the glial fibrillary acidic protein (GFAP).

astrocytes

Scar like multiple sclerosis

Not present in PNS (no scarring)

Which glial cells can myelinate more axons

Oligodendrocytes up to 20 axons in CNS

Schwann only 1 axon in PNS

______ channel maintain membrane stability, myotonia linked to dysfunction

Chloride

Lambert-Eaton Syndrome is when autoantibodies against Ca channels cause impaired presynaptic _____ release

ACh

Which acetylcholine neurotransmitter receptor is ionotropic and which is metabotropic

Nicotinic is ionotropic (fast)

Muscarinic is metabotropic (slow) (G protein)

______ coats the membrane of the vesicle that has released neurotransmitter

Clathrin

Recycles the vesicle that has already released neurotransmitter

Acetycholine is synthesized by _______ and ______ by choline acetyltransferase (ChAT)

acetyl-CoA and Coline

The classic antagonist of the muscarinic effect is _____, and the best-studied blocker for the nicotinic receptor is the _____ _____ α-bungarotoxin.

atropine, snake venome

Alzheimer’s disease is impairment of cholinergic neruon in brain septum caused by _____ protein tangles. ______ inhibitor such as donepezil with _____ receptor can be used for cognitive improvement

tau, AChE, M2

______ deficiency causes beriberi and can cause wet (cardiovascular) or dry (Neurological) beriberi and Wernicke-Korsakoff Syndrome

Thiamine (B1)

To overcome dopamine deficits in some of these diseases, L-DOPA, its precursor, is administered because why?

easily crosses blood brain barrier

What is the action of phentolamine and propranolol

Phentolamine blocks a-adrenergic receptor

Propranolol blocks b-adrenergic receptor

Epilepsy can be caused by excess ______ or deficiency of ______ and also the mineral _______

glutamate, GABA, zinc

What is the autonomic neurotransmitter for pre and post synaptic and para and sympathetic

All are acetylcholine except

Postsynaptic sympathetic is norepinephrine