BARBITURATES

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8 Terms

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Barbiturates

are used as hypnotic and sedative agents,

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Thiopental

ultrashort- acting

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Phenobarbital

long-acting

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GABA-mediated chloride

Interaction with a barbiturate receptor leads to enhanced________ currents and results in synaptic inhibition.

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Ultrashort-acting barbiturates

Highly lipid soluble

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Long-acting barbiturates - Primidone (Mysoline)

Distributed more evenly and have long elimination half-lives, making them useful for once-daily treatment of epilepsy

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• Methohexital

deaths were reported as little as 1– 3 mg/kg

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  • pupils are usually small or midposition

  • lose all reflex activity

  • Hypothermia

Deep coma