lecture 5 - T cell development & maturation

T-cell progenitors develop in the ____ ______ and migrate to the ______

T cell receptor ____ rearrange in the thymus

Immature T cells that recognise self ___ survive

Immature T cells that recognise self _____ undergo ________

Mature T cells migrate to the peripheral _______ organs and are activated by encountering _______ _______

Activated T cells migrate to sites of ________ and eliminate infection

bone marrow

thymus

genes

MHC

antigens

apoptosis

lymphoid

foreign antigens

infection

T cells (_____cytes) have two lineages : ___ and ____

this is facilitated by _____ signalling

CD3^-4^-8^- describes a _______-negative thymocyte

______ describes a CD4+ small resting single-positive thymocyte

thymocytes

CD4+

CD8+

Notch

double

CD4⁺8^-

the thymus is composed of two parts: _____ and ______

cortical ______ cells express self-___.

double positive _______ that moderately bind to _____ commit to CD8+ lineage

those that bind to ______ commit to CD4+ lineage

the binding has to be perfect: ________ zone

this is called _____ selection

_______ epithelial cells present self-_______

binding too strongly commits the thymocyte to ________ to prevent _______

this is called ______ selection

this whole process is called thymic _________

cortex, medulla

epithelial, MHC

thymocytes, MHC I

MHC II

Goldilocks

positive

medullary, peptides/antigens

apoptosis, autoimmunity

negative

education

just

just