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What are the three main layers of the integument?
Epidermis, dermis, and hypodermis
What is the epidermis made of?
Stratified squamous epithelial tissue
What is the dermis primarily made of?
Loose connective tissue with collagen, nerves, glands, and vessels
What is another name for the hypodermis?
Subcutaneous layer
Which layer contains adipose tissues stores energy and insulates the body?
Hypodermis
Which layer stores adipose energy and insulates the body?
Hypodermis
Which layer is avascular (contains no blood vessels)?
Epidermis
Which layer nourishes the epidermis?
Dermis (via diffusion)
What is the main function of the epidermis?
Protection from external environment
What are the five strata of the epidermis (superficial to deep)?
Corneum, lucidum, granulosum, spinosum, basale
What layer is only found in palms and soles?
Stratum lucidum
What layer contains dividing stem cells?
Stratum basale (stem cells)
What layer is known as the first line of defense?
Stratum corneum
Which layer helps form a waterproof barrier?
Stratum granulosum
What protein strengthens and waterproofs the skin?
Keratin
What cells produce keratin?
Keratinocytes
What cells produce melanin?
Melanocytes
What layer are melanocytes and stem cells found in?
Stratum basale
What determines skin color — number or activity of melanocytes?
Activity of melanocytes
What type of UV light stimulates melanin production?
UVB radiation (~320 nm)
What disease is caused by malignant melanocytes?
Malignant melanoma
What condition causes rapid keratinocyte division and flaky skin?
Psoriasis
What structures anchor the epidermis to the dermis?
Basement membrane and dermal papillae
What is the function of dermal papillae?
Strengthen attachment and regulate hair growth
What are 'prickle cells,' and where are they found?
Keratinocytes with desmosomes in stratum spinosum
Which layer is the site of basal cell carcinoma?
Stratum basale (carcinoma)
What vitamin does the skin help synthesize?
Vitamin D (cholecalciferol)
What organ systems activate vitamin D after its creation in the skin?
Liver and kidneys
What is the main function of vitamin D in the body?
Promotes calcium absorption and transport
Which layer contains sensory receptors and glands?
Dermis
What are the main accessory structures of the dermis?
Hair follicles, sweat glands, sebaceous glands, receptors, blood vessels
What connects the dermis to the epidermis and makes fingerprint?
Dermal papillae
What is the smooth muscle attached to each hair follicle?
Arrector pili muscle
What causes goosebumps?
Contraction of the arrector pili muscle
Where does hair growth begin?
Hair bulb at the base of the follicle
What provides blood and nerve supply to the hair bulb?
Hair papilla
What is the main component that gives hair hardness?
Keratin
What gives hair its color?
Melanin
How many hairs does the human body approximately have?
About 2.5 million
What type of hair is soft and fine?
Vellus hair
What type of hair is coarse and pigmented?
Terminal hair
What substance do sebaceous glands secrete?
Sebum
What triggers the secretion (release) of sebum from sebaceous glands?
The contraction of the arrector pili muscle triggers the release of sebum by squeezing the sebaceous gland.
What are the main components of sebum?
Triglycerides, proteins, cholesterol, electrolytes
What is the main function of sebum?
Lubricates and waterproofs hair and skin (OIL)
What are sweat glands also called?
Sudoriferous glands
What are the two main types of sweat glands?
Apocrine and eccrine
Which sweat glands open into hair follicles?
Apocrine glands
Which sweat glands open directly to the skin surface?
Eccrine glands
Where are apocrine glands found?
Axilla and genital regions
What type of sweat glands help regulate body temperature?
Eccrine glands
What causes body odor?
Bacterial breakdown of apocrine secretions
What makes eccrine sweat slightly antibacterial?
A peptide with antibiotic properties in sweat
What structures detect pain, pressure, and temperature?
Sensory receptors in dermis(ans)
What gives nails their pink color?
Blood vessels under the nail bed
What is the visible part of the nail called?
Nail body
What is the growing region of the nail called?
Nail matrix/root
What is the cuticle’s anatomical name?
Eponychium
What part of the epidermis extends over the nail base?
Stratum corneum
What is the main function of the integument?
Protection, temperature regulation, sensation, and vitamin D synthesis
How does the skin regulate body temperature when overheated?
Sweat glands activate; blood vessels dilate
How does the skin conserve heat in cold conditions?
Sweat glands close; blood vessels constrict; shivering may occur
What brain region controls body temperature?
Hypothalamus
What is the body’s normal core temperature set by the hypothalamus?
About 98.6°F (37°C)
What type of heat transfer occurs when body heat radiates to the environment?
Radiation
What type of heat transfer occurs through direct contact?
Conduction
What type of heat transfer occurs via moving air around the body?
Convection
What type of heat loss involves evaporation of sweat?
Evaporation
What condition results from dangerously low body temperature?
Hypothermia
What are symptoms of hypothermia?
Shivering, confusion, lethargy, loss of reflexes, unconsciousness
What condition occurs from overheating in humid conditions?
Hyperthermia
What are symptoms of hyperthermia?
Dizziness, headache, cramps, fatigue, nausea
What does the hypothalamus do when body temp rises?
Activates sweat glands and dilates vessels
What does the hypothalamus do when body temp drops?
Closes sweat glands and triggers shivering
What structure of the skin is responsible for touch and pressure detection?
Sensory receptors in dermis
What type of connective tissue predominates in the dermis?
Loose connective tissue with collagen and elastic fibers
What kind of tissue predominates in the hypodermis?
Adipose and connective tissue
What happens to skin cells as they move from deep to superficial?
They die and become keratinized
What skin structure makes fingerprints?
Dermal papillae
What layer of skin contains nerve endings for pain and temperature?
Dermis
What layer of skin produces new skin cells?
Stratum basale
What pigment protects against UV radiation?
Melanin
What is the largest organ of the body?
Skin
What happens to melanin production with sun exposure?
Increases, darkening the skin