Pharmacology 4 Side Effects

antiplatelet

bruising hematoma gi bleeding tarry stools

warfarin

hemorrhage fetal hemorrhage teratogenesis

rivaroxaban apixaban

bleeding - less than warfarin

anticoagulants

hemorrhage hematuria epistaxis ecchymosis bleeding gums thrombocytopenia hypotension

digoxin

dysrhythmias hypokalemia bradycardia elevated digoxin levels n/v/d anorexia ha drowsiness visual disturbances fatigue

adenosine

asystole sinus bradycardia dyspnea hypotension facial flushing

statins

hepatotoxicity myopathy rhabdomyolysis

propranolol metoprolol

bradycardia decreased av conduction reduction of contractility asthmatic effects hypoglycemia

verapamil diltiazem

reflex tachycardia hypotension av block hf peripheral edema constipation

interactions-beta blockers

heparin

hemorrhage hit

nitroglycerin

vasodilation-ha postural hypotension reflex tachycardia

amiodarone

pulmonary cardio thyroid toxicity liver injury photosensitivity toxic in pregnancy

no grapefruit

interactions-digoxin warfarin diltiazem statind diuretics

propanolol

heart block hypotension bronchospasm

lidocaine

drowsiness confusion paresthesia tingling burning

interactions-digoxin

enoxaparin

bleeding thrombocytopenia

clopidogrel

bleeding ttp

streptokinase alteplase

bleeding antibody production hypotension fever not for long term

contradiction-hx of uncontrolled hypertension

asprin

risk of gi bleed hemorrhagic stroke

verapamil diltiazem

constipation vasodilation-dizziness, facial flushing, ha, edema bradycardia av block

beta adrenergic blockers

propanolol metoprolol

hypotension bradycardia palpations n/v bronchospasm impotence

amlodipine

vasodilation-dizziness facial flushing ha lower body edema

hydralazine

postural hypotension reflex tachycardia

captopril losartan

hypotension hyperkalemia intractable cough angioedema renal failure when renal a stenosis

nitroprusside

excessive hypotension cyanide poisoning

clonidine

dry mouth sedation rebound hypertension if abruptly stopped

aliskiren

angioedema cough hyperkalemia fetal harm/death diarreha

spironolactone

hyperkalemia gynecomastia mental irregularities impotence hirsutiusm deepening of voice

propranolol metoprolol

hypotension bradycardia palpations hypoglycemia w/ insulin use n/v bronchospasm impotence

lisinopril

hyperkalemia hypotension fetal injury cough angiedema renal failure w/renal stenosis digoxin increase hyperkalemia

thiazide diuretics

hypokalemia hypotension

loop diuretics furosemide

hypokalemia hypotension

potassium sparing spironolactone

hyperkalemia hypotension

irbesartan losartan

angioedema renal failure fetal injury

furosemide torsemide

dehydration hypotension tachycardia ototoxicity electrolytes-hypokalemia hyponatremia hypochloremia hyperglycemia hyperuricemia

interactions-digoxin ototoxic drugs

hydrochlorothiazide

dehydration hypotension tachycardia

electrolytes-hypokalemia hyponatremia hypochloremia hyperglycemia hyperuricemia

contraindications-pregnancy lactation digoxin

spironolactone triamterene

hyperkalemia blue urine

interactions-thiazide/loop diuretics raise k levels

mannitol

dehydration-dizziness confusion postural hypotension constipation