Micro Bio quiz - ch 14

All of the following are involved in Type 2 hypersensitivity except:

IgE

Whereas autoimmune disorders are more likely in girls/women, some inherited immunodeficiency disorders are more likely in boys/men.

True

A woman with Type O blood (choose the true statement):

Produces both Type A and Type B reactive antibodies in her body

Causes of immunosuppression include:

all of the above

• inherited mutations

• viral infections

• cancer/tumors

• the effects of certain drugs

Which of the following would normally not be considered a treatment for an autoimmune disorder?

bone marrow transplant

Each of the following can result in acquired immune deficiencies except:

bacterial infection

Histamine causes all the following except:

increased sensitivity to pain

Myasthenia Gravis disease arises from the production of autoantibodies against:

Acetylcholine receptors on skeletal muscle

Which of the following statements is incorrect regarding Type III hypersenstivity?

The symptoms are progressive and life threatening long after the antigen exposure has been stopped

Which of the following autoimmune diseases primarily affects the nervous system?

Multiple sclerosis

Which type of rejection process is very rapid and primarily mediated by antibodies?

hyperacute

The chemical mediator that causes prolonged bronchospasm, vascular permeability and mucus secretion in asthma patients:

Leukotriene

When preparing for a tissue graft, it is of utmost importance that the host and donor have similar (if not identical):

HLA proteins

Which of the following would not be a potenial treatment for those suffering from immunodeficiency?

Drugs like cyclosporin, cyclophosphamide or methotrexate

Inherited genes are partly responsible for a pre-disposition to autoimmunity. What can serve as a trigger?

all of the above

• infection with a bacterium or virus

• recent surgery or tissue damage

• inappropriate expression of MHC class 2 molecules

• inappropriate survival of autoreactive T and B cell clones

__________ disease is an autoimmune disorder (type II) which results in an over activation of the Thyroid by antibody binding to the Thyroid Stimulating Hormone receptor.

Graves

Corticosteroids will:

inhibit the activity of lymphocytes

A child/person suffering from recurrent viral/fungal infections, with also possible impairment of some antibody responses, would likely have an underlying:

T cell deficiency

Hemolytic anemias are IgE-mediated Type 1 hypersensitivity reactions

False

Atopy and anaphylaxis fall under which hypersensitivity type?

type 1

Which of the following statements regarding IgA deficiency is true? (See slides and text).

It is likely to result in recurrent mucosal (respiratory and GI) infections.

What is the term for grafted tissue between two (genetically distinct) individuals? The graft would be considered a(n) __________.

allograft

Certain autoimmune conditions, as well as Rh-factor mediated blood rejections, are passed transplacentally from mother to the developing fetus because they are mediated by:

IgG antibodies

A severe congenital immunodeficieny affecting both T and B cells/activites is referred to as:

SCID

Potentially curative treatments for pediatric SCID patients include the following except:

injections of immune globulin (passive immunotherapy)

Which of the following condtions and hypersensitivity is mismatched?

Hay fever - Type IV hypersensitivity

Isotype switch and production of IgE antibodies by B cells is directed/facilitated by which cell type?

T helper 2 (CD4) cells

The most-tolerated (least rejected) tissue graft type would be an:

autograft

Although there are exceptions, a patient with an autoimmune condition is likely to be:  (choose all that apply)

• female

• have relatives with a history of autoimmunity

Which event occurs with the initial, sensitizing dose of allergen?

Production and binding of IgE by their Fc regions to mast cells and basophils

Induction of Type I hypersensitivity by a Mast cell:

all of the above

• requires allergan cross-linked surface IgE

• releases pre-formed mediators (i.e. histamine) in response to the allergan

• releases leukotrienes and prostaglandins which casue vasodilation and bronchiole restriction

• happens in a very short time frame after activation

The potential for hemolytic disease of the newborn occurs when:

Fetal Rh cells enter an Rh- mother

A blood transfusion reaction due to an ABO blood group difference between the donor and recipient occurs due to:

IgM antibodies participating in Type II hypersensitivity

Epinephrine:

reverses constriction of the airways

Allergies run in families because:

The relative production of IgE is inherited.