module 4: tolerance & autoimmunity
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Last updated 1:54 AM on 4/1/26
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5 Terms
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tolerance
unresponsiveness to self-antigen
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surrogate markers of se
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central tolerance
self-reactive T & B cell clones are eliminated in primary lymphoid organs
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peripheral tolerance
self-reactive T & B cell clones are deleted, rendered anergic, or actively suppressed by T regulatory cells in secondary lymphoid organs
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autoimmunity
breakdown of tolerance mechanisms. immune response against self antigens
