Proton Pump Inhibitors Formulations- A Case Study
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7 Terms
What is a proton pump
An integral trans-membrane protein (H⁺/K⁺ ATPase) in the parietal cells of the stomach
Pumps proton into the stomach
By using ATP, a positively charged hydrogen ion replaces a positively charged potassium ion
What are Proton Pump inhibitors and name 5 PPIs that are available for clinical use
PPIs are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production
Omeprazole
Lansoprazole
Esomeprazole
Pantoprazole
Rabeprazole
What are Proton Pump Inhibitors used for
Peptic Ulcers
Gastric Ulcers
Duodenal Ulcers
GORD
Too much gastric juices
How does Omeprazole work
Its an inactive drug
Converts to active sulfonamide intermediate in the secretory canniculi of the parietal cell
Active Sulfonamide binds to and inactivates the H+K+-ATPase
Name some of the tablets that contain Omeprazole
Losec MUPS® tablets
; Losamel® tablets
Name some excipients and functions of it of ; Losamel® tablets
Betadex- solubility enhancers
Lactose Monohydrate- binder
Maize starch
Name some excipients in Losec Mups® Tablets
Cellulose microcrystalline
Glycerol monostearate 40-55
