BIOCHEM - Tricarboxylic acid cycle

mitochondria

where is the TCA cycle located?

covalent modification (phosphorylation)

the key means of regulation is _____

acetyl CoA

what is the fuel for the TCA cycle?

citrate

two carbon acetyl unit condenses with a four-carbon component to yield the six-carbon tricarboxylic acid _____

oxidative decarboxylation

two carbons come in with the acetyl unit, two leave as CO2

citrate synthase

the TCA begins with the condensation of oxaloacetate with the acetyl group from acetyl CoA

ADP

enzyme in the skeletal and heart muscle cells

GDP

enzyme in the tissues that perform many anabolic reactions, such as the liver

substrate channeling

the efficiency of the TCA cycle is enhanced because reactions can pass directly from one active site to the next through connecting channels

aerobic

TCA is strictly _____

oxaloacetate

formed by the carboxylation of pyruvate by the enzyme pyruvate carboxylase

glucose

if energy charge is high, oxaloacetate is converted to _____

replenished

if energy charge is low, oxaloacetate is _____

anaplerotic reaction

the generation of oxaloacetate by the carboxylation of pyruvate is _____