Organic Chemistry 2 Final Exam

Enamines

N is bonded to C instead of O. One H from the amine replaces the O. Only with 2° amines. Double bond forms between the C

Imines

N is double bonded to C instead of O. One H from the amine replaces the O. Only with 1° amines

Haloform reaction

When there is a methyl ketone and excess X2 is added, the methyl group is replaced by an O-, resulting in CHX3

Hell Volhard Zelinsky reaction

A carboxylic acid where an H on the alpha carbon is replaced by Br. OH is also temporarily replaced by Br

Aldol reaction

2 molecules of an aldehyde or ketone react in the presence of a base to bond with each other

Claisen condensation

Same as an aldol reaction but with esters. Also, the OR group detaches, unlike the H in the aldol reaction. No OH forms

Malonic ester synthesis

Diethyl malonate is turned into acetic acids using NaOEt,H3O, and heat. NaOEt replaces an H with the adding group and H3O/heat replaces COOEt with H and the other with COOH

Acetoacetic ester synthesis

Same as malonic ester synthesis except there’s only one COOEt which gets completely replaced by an H

Michael reaction

A nucleophile is added to the beta carbon

Robinson annulation

2 cyclohexenes form under OH in H2O

Fischer esterfication

Addition of an alcohol to a carboxylic acid in the presence of an acid, typically H2SO4, to form an ester. The group coming in replaces the H in the alcohol

Halogenation

Benzene reacts with Cl2 or Br2 in the presence of an acid to perform a substitution

Friedel crafts alkylation

Benzene reacts with an alkyl halide and acid, typically AlCl3, to form an alkyl benzene. Similar to halogenation except a new group attaches instead of Cl or Br

Friedel crafts acylation

Benzene reacts with an acid chloride (RCOCl) and acid, typically AlCl3, to form an aryl ketone