Hallucinogens intoxication and withdrawal

Mechanism of action of lysergic acid diethylamide

5-HT2a receptor AGONIST

Manifestation of LSD intoxication

Perceptual distortion (visual, auditory)

Depersonalization

Anxiety

Paranoia

Psychosis

Flashbacks

Mydriasis

MOA of Cannabis/ cannabinoids

CB1 receptor agonist

Manifestation of cannabis intoxication

Euphoria

Anxiety

Paranoid delusions

Perception of slowed times

Impaired judgement

Social withdrawal

Increase appetite

Dry mouth

Conjunctival injection

Hallucinations

Manifestations of cannabis withdrawal

Irritability

Anxiety

Depression

Insomnia

Restlessness

Decrease in appetite

MOA of MDMA (ecstasy)

Induces reversal of transporters for monoamines ( SERT > DAT, NET), Causing an increase in neurotransmitter release

MDMA intoxication symptoms

Euphoria

Hallucinations

Disinhibition

Hyperactivity

Increase in thirst

Bruxism

Distorted perceptions

Mydriasis

What are the life threatening effects of MDMA intoxication

Hypertension

Tachycardia

Hyperthermia

Hyponatremia

Serotonin syndrome

MDMA withdrawal symptoms

Depression

Fatigue

Change in appetite

Difficulty concentrating

Anxiety

MOA of phencyclidine (PCP)

NMDA receptor antagonist

PCP intoxication symptoms

Violence

Nystagmus *****

Impulsivity

Psychomotor agitation

Tachycardia

Hypertension

Analgesia

Psychosis

Delirium

Seizures