Microtubule Inhibitors - Dykhuizen

Role of microtubules in cell division

Essential for mitotic spindles. Moves chromosomes into daughter cells during mitosis

Spindle assembly checkpoint requirements

Requires kinetochore attachment and tension

Microtubule destabilizer: Vinca alkaloids

1) MOA + cause

2) Critical for + effects

3) examples + SE

binds to tubulin which inhibits microtubulin assembly causing mitotic arrest. Critical for nerve axon cell function which leads to peripheral neuropathy. Vincristine has severe local inflammation and neurotoxicity that is dose dependent and dose limiting

Microtubules stablizer: Taxane

1) MOA

2) Example and Toxicity

Bind to tublin which promotes microtubulin assmebly and blocks depolymerization which causes mitotic arrest. Paclitaxel has toxicity of myelosuppression that is dose lmiiting and neurotoxicity

Which of the following block the polymerization of tubulin?
A. Paclitaxel
B. Vincristine
C. Etoposide
D. Doxorubicin

Vincristine