Sulfonamides and Trimethoprim
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Flashcards about Sulfonamides and Trimethoprim.
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6 Terms
1
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What are Sulfonamides?
Structural analogues of PABA, which is a precursor for dihydrofolic acid.
2
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What is Trimethoprim?
Inhibits bacterial dihydrofolic acid reductase (DHFR), an enzyme needed for folic acid synthesis.
3
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What is dihydropteroate synthase?
An enzyme needed for folic acid synthesis, competitively inhibited by high levels of PABA or a PABA analogue.
4
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Folic acid synthesis
Inhibition of what, results in the disruption of DNA synthesis and thus the inhibition of bacterial growth?
5
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What is Methotrexate?
An anti-neoplastic drug that selectively inhibits human DHFR.
6
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What is Pyrimethamine?
An anti-parasitic agent that selectively inhibits DHFR in protozoa.
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