PACOP Violet - Organic Pharmaceutical Chemistry

Aripiprazole

The ff agents are used to treat hyperacidity and GI ulceration, EXCEPT:

Cytotek

Ranitidine

Omeprazole

Aripiprazole

Maalox

primary alcohols

reduction of aldehydes yield

Dynacin binds to the __________ ribosomal subunit

Dynacin binds to the __________ ribosomal subunit

CnH2n

General formula for alkenes

Penicillamine

This agent is used to chelate copper in which an excess amount causes Wilson's disease

antifungal

Imidazole nucleus is primarily found in what type of anti-infective agents

3,7-dimethylxanthine

Theobromine is also known as

Nucleus

The receptor of steroidal hormones are primarily found in the ...?

Decreases half-life of drugs

The ff are effects of protein binding, EXCEPT:

Decreases free drug molecules

Limits the amount available for the metabolism

Decreases half-life of drugs

Prevent rapid excretion of the drug

covalent bond

DNA alkylating agent binds to its target by means of what bond?

Hg (Mercury)

Thimersosal is a preservative that contains?

Methylparaben

A paraben used to preserve the drug from molds

Increasing the molecular weight

Preservatives like parabens increase their preservative property by

random screening

An approach in drug discovery wherein there is already an existing drug that can be used to identify a new lead compound

ion channel

Sodium pump is an example of

hydrogen peroxide

Radical reactions may also proceed using this reagent

99%

Azeotropic distillation of benzene is done in what concentration of ethanol?

enamine

When a carbonyl group reacts with a secondary amine, what will be the resulting product?

Propane

Which of the ff compounds can be use to synthesize primary alcohols.

propane

formaldehyde

3-chloropentane

acetone

Ethanamine

anisole

Methoxybenzene is also known as

Ceftriaxone

Which of the ff cephalosporin is excreted in Bile

cefixime

cefotaxime

ceftriaxone

moxalactam

loracarbef

Methylparaben

Preservative use for molds

N-octanol

Compound use to identify the partition coefficient in-vitro

Alanine aminotransferase (ALT)

Aztreonam can elevate this enzyme

Deamination

Isoniazid is metabolized by humans principally by

avidity

Total affinity of the ligand to its receptor

Xylene

Dimethylbenzene is also known as

Undecylanic acid

compound derived from the destructive distillation of castor oil and it is use as a keratolytic agent

GABA receptors

The following are example of G protein coupled receptors, except

covalent bonding

DNA Alkylating agent binds to its target by means of what bond?

Antagonist

In the presence of a full agonist, a partial agonist becomes

Rosuvastatin

A long-acting HMG-CoA Reductase inhibitor

CYP 3A4

This is the most important CYP 450 isozyme that is responsible for the metabolism of almost 50% of the drugs available in the market

Hypothesis of Paton

a theory that advances the idea that maximum pharmacologic effect can be obtained if all the receptors are occupied

nitric oxide

The anti-angina effect of nitrates is primarily due to the release of what gas?

Indapamide

Diuretic that acts on the distal convoluted tubule

Hydroquinone

What is 1,4- dihydroxybenzene

radical reactions

Halogenation of alkanes is possible in what type of reaction

Ortho position; Para position

Alkylation of aminobenzene will likely proceed to what position

Acid anhydride

a derivative of two carboxylic acids, in which the compound is formed by the removal of one molecule of water in two RCOOH

Electrophilic substitution

Benzene undergoes what type of reaction?

Tertiary

Which of the ff carbocation intermediate is the most stable?

Primary, Secondary, Tertiary, Quarternary

Markovnikov's Rule

Ragioselectivity of an organic reaction in which the orientation of the substituents stabilizes the product is governed by

Tautomerization

An enol is not a stable compound because it undergoes

Heroin

Acetylation of Morphine yields

Phenobarbital

Primidone is a prodrug that is converted into:

Para position

In phenols, substitution at _____ position increases bactericidal activity

Ketone or Ether

C3H6O can be a/an

Saturable kinetics

Zero order drug metabolism

Inhibition of cell wall synthesis

Glycopeptides exert their mechanism of action via

Cefuroxime

Which of the ff cephalosporins can cross the blood brain barrier?

Cefprozil

Cefuroxime

Cefalexin

Cefmetazole

99%

Concentration of dehydrated alcohol

Olefinic oxidation

Carbamazepine undergoes what metabolic pathway

Thiotepa

Triethylenephosphoramide is an active metabolite of

Norfloxacin

least active agent among all fluoroquinolones

Isoniazid

Antitubercular drug that is in combination with pyridoxine

CD4

Th is the target site of HIV

Amikacin

Acylation of the amino group in the second ring of aminoglycosides produces

Thimerosal

Preservative in BCG Vaccine

Vancomycin

Redman syndrome is seen in

PO

Tigemonam is primarily administered in what route?

low surface tension

characteristic of a substance that gives its ability to spread into wounds

Inhibition of the production of folic acid is the mechanism of action of

Sulfamethoxazole

Inhibition of the production of folic acid is the mechanism of action of

Phenol

Violet color result with ferric chloride is commonly observed in

Methylation

Biogenic amines are inactivated primarily by

rash

Nevirapine is known to cause ______ for HIV patients with low CD4 count

Ergosterol

Polyene antifungals bind to ______ to promote ion leakage resulting to fungal death