Type III Hypersensitivity: Immune Complex-Mediated Inflammation

IgG

What is the main antibody isotype in type III hypersensitivity reactions?

Complement and phagocytes

What is the effector mechanism for type III hypersensitivity reactions?

Kuppfer cells

Immune complexes are normally removed by what?

IgG, antigen

Type III hypersensitivity reactions occur due to low levels of _______ and re-exposure to high concentration of ________

Neutrophils (leads to inflammation within the vessel wall)

Complement activation results in recruitment of what?

Vasculitis

IV exposure resulting of immune complexes depositing in the blood vessel walls leads to what?

Nephritis

IV exposure resulting of immune complexes depositing in the renal glomeruli leads to what?

Arthritis

IV exposure resulting of immune complexes depositing in joint spaces leads to what?

Arthus reaction

Subcutaneous exposure resulting in immune complexes depositing in perivascular area leads to what?

Farmer's lung

Inhaled allergens with immune complexes depositing in alveolar/capillary interface lead to what?

Serum sickness

A systemic hypersensitivity condition resulting from immune complex deposition in tissue and blood vessels that causes tissue damage through complement activation

Purpura hemorrhagica

A dangerous sequel to strangles; due to excessive immune response following a bout of strangles or after vaccination; inflammation of blood vessels - vasculitis

Antisera derived from horse serum

Historically, what were the most common causes of serum sickness?

1. Blue eye from canine adenovirus 1

2. FIP

3. Classical swine fever

What are some infectious agents associated with type III hypersensitivity reactions?