Adaptive immunity

Epitope

End of an antigen

primary immune response

Very FIRST TIME you get an infection from a microbe, virus, etc.

Secondary immune response

Exact same strain; gets recognized; thousands of cells see foreign invader, and infection won’t be nearly as bad when you FIRST got the infection EVER in your life

Antibody mediated immunity

Part of immune system that is CONTROLLED/REGULATED By antibodies

Bone marrow

Where do B-cells mature?

Naïve B cell

What are B cells called when let out into blood?

Sensitized B cell

What is a Naïve B cell called when it finds foreign antigen?

Sensitized B cells mutate its B cell receptors and will then get activated by a helper T cell

How are antibodies created?

Proliferate

Reproduces a ton

Neutralization

Covers attachment sites and renders it to infect tissues

Opsonization

Surrounds pathogen and enhances phagocytosis

Immobilization

Can’t move; only works on bacteria with flagella; interferes with mobility

Agglutination

Clump forming; clumps so big can’t get into cell therefore prevents infection

IgM

FIRST antibody produced in primary response

IgG

MOST ABUNDANT in fluid that STAYS IN your body, provides LONGEST immunity, ONLY ONE THAT CAN CROSS PLACENTA BARRIER

IgA

MOST ABUNDANT in fluids that LEAVE your body

IgE

Binds to and takes care of ALLERGENS

Naïve T cell

What is a T cell called when let out into blood?

It will find foreign antigen bounded to MHC and called Sensitized T cell

What is a naïve T cell called when it finds foreign antigen?

It becomes a activated T cell

What happens when a sensitized T cell takes foreign antigen from the MHC?

Cytotoxic T cells (Tc)

ONLY interact with MHCI RECEPTORS

MHCI

What do all nucleated cells have?

Edongenous antigen

What do MHCI hold?

CD8

What receptors do cytotoxic T cells have?

Helper T cells (Th)

ONLY interact with MHCII receptors

MHCII

What do APCS (antigen presenting cells) have?

Exogenous antigen

What do MHCII hold?

CD4

What receptors do helper T cells have?

Memory B cells and plasma cells

What do B cells differentiate?

Memory T cells and Effector cells

What do T cells differentiate?

Dendritic, B cells, and macrophages

What cells are antigen presenting cells?