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1 pound of fat= _____ calories
3500
what happens to fat cells once you reach maximum size
number of fat cells increases
in weight loss how does fat cells change
same number but the cells decrease in size
components of metabolism of fat cells
lipoprotein lipase, dietary fat oxidation, set point theory
What is a lipoprotein lipase
an enzyme that promotes fat storage
where are high levels of lipoprotein in men
stomach cells
where are high levels of lipoprotein in women
breasts and thigh cells
what is the correlation between body fat and dietary fat oxidation
high body fat= low oxidation
negative correlation
what is set point theory
metabolism goes back to original weight after weight gain or loss
homeostasis/balance
hormones that cause genetic obesity
leptin and ghrelin
what is leptin
hormone in hypothalamus that surpasses appetite and increases energy expenditure
what does leptin promote
weight loss
what correlation does body fat and leptin have
positive correlation
body fat increases= leptin increases
what is ghrelin
a hormone that increases appetite and decreases energy expenditure
how does lack of sleep effect ghrelin and leptin
increases ghreling and decreases leptin
how does gastric bypass work
added tube that connects to jejunum and makes food bypass main part of SI
benefits of a gastric bypass
can be reversed and does not involve any foreign objects to be placed in body
how does gastric banding work
creates a pouch and put a top of stomach, band is placed to tighten or loosen and add or remove fluid
benefits of gastric banding
temporary and less invasive
how does sleeve gastrectomy work
removed 70-80% of stomach and rest is stapled back together
energy balance is
energy in=energy out
what part of brain controls food intake
hypothalamus
what is satiation
signal to stop eating
what is satiety
feeling of fullness
can be override by stress
what triggers desire to eat
endorphins
what is postingestive influences
happens after food enters GI tract, and that food triggers stretch receptors and then the nutrients in SI elect hormones
what is post absorptive influences
happens after nutrients enter blood and signal brain about availability, use and storage
what happens when nutrients dwindle in body
satiety stops and hunger starts again
how do you stay in satiety
eat protein rich foods
eat low energy dense foods
eat high fiber foods
influences on how many calories you burn
frequency, intensity and duration of workout
what is the correlation between body surface area and calories burned
positive correlation
increased body surface area= increased calories burned
what factors decrease BMR
starvation
drugs
stress
aging
what factors increase BMR
fever
extreme temps
thyroxine
smoking
exercise
caffeine
How do you calculate BMI
weight in pound/ height in inches / height again * 703
bmi for underweight
less than 18.5
bmi for healthy weight
18.5-24.9
bmi for overweight
25-29
bmi for obese
over 30
how is body fat distributed in men
apple shape
high risk for disease
how is body fat distributed in women
pear shape
low risk for disease
anorexia nervosa
patients who have major body dysmorphia ad have fear of gaining weight
consequences of anorexia
malnutrition, anemia, fertility problems
bulimia nervosa
patients who have normal weight because they binge eat and then throw it up
consequences of bulimia
UTIs, electrolyte imbalance, irritated GI tract
cycle of female athlete triad
eating disorder leads to amenorrhea that leads to osteoporosis
what is amenorrhea
when someone looses their period
what are pyruvate 3 location options
convert back to glucose
go to acetyl CoA
for lactase
what are amino acids that convert to pyruvate
glucogenic
what are amino acids that convert to acetyl CoA
ketogenic
are all carbs, lipids and proteins energy yielding
yes
which nutrient does not produce glucose
fatty acid lipids
which nutrient does not produce amino acids and body proteins
fatty acid lipids
can all nutrients store fat
yes
what is anabolism
building up
requires energy
ex: amino acids to protein
what is catabolism
breaking down
releases energy
ex: glycogen to glucose
what is ATP
quick energy molecule that generates heat
why can glycerol and glycogenic amino acids go into pyruvate
because they both have 3 carbons each
why can ketogenic amino acids and fatty acids go into acetyl CoA
because fatty acids have 2 carbons and ketogenic AA have 6 carbons
where does acetyl CoA go
joins the TCA/citric acid cycle
what happens in the TCA/citric acid cycle
carbon dioxide is released
what happens when you have too much carbs, protein or fat
it is broken down to pyruvate then turned to glycerol and stored in stomach, hips, etc.
What is anaerobic
quick energy needs that does not require oxygen
ex: sprinting
what is aerobic
slow energy needs that does require oxygen
example of anaerobic process
pyruvate turning into lactate
what does aerobic process activate
pyruvate to become acetyl CoA
what happens to metabolism when you take in too much protein
it builds fat instead of muscle and will not enter energy pathway
what must happen before amino acids can enter pathway
denaturation
what is deamination
removal of an amino group from AA when there is an excess of nitrogen
what is ketosis
when you body doesn't have enough carbs to burn energy
what is a result of ketosis
body burns fat and makes a type of acid called ketones
what is alcohol dehydrogenase
enzyme that breaks down alcohol
why is protein different from other nutrients
includes nitrogen
what is the chemical structure of amino acids
amino group (with N2), acid group, hydrogen and side group that varies
What are 9 essential amino acids
AA that cannot be made by body
what are limiting amino acids
do not provide full amounts of the 9 essential AA and limit the amount of protein that can be synthesized
AA sequences
connected by peptide bonds
what is a dipeptide
2 amino acids joined in condensation reaction
what does hemoglobin consist of
4 polypeptide chains
why is protein synthesis different in each person
depends on each persons genes/DNA
what is a sickle cell
sequencing error in hemoglobin
what enzyme is involved in protein digestion
pepsin (inactive pepsinogen and active pepsin)
how are AA broken down in SI
go from polypeptides to tri and di peptides because of protease
what is denaturation
unfolding of proteins that makes it unstable
example of denaturation of protein
cooking an egg
when does positive nitrogen balance occur
growth and pregnancy
what is negative nitrogen balance
getting rid of more than you are taking in
When does negative nitrogen balance occur
sickness, bedridden, starvation
what happens to unused AA/N2
released into blood, goes to liver and makes ammonia
what happens when you eat more proteins
you pee more
what is urea synthesis
2 ammonia + carbon dioxide
what foods are high quality proteins
animal protein and eggs
what foods are poor quality proteins
plants, beans, corn, etc
what can help facilitate use of proteins
vitamins and minerals
what is components of kwashiorkor
inadequate protein with adequate food energy
how does kwashiorkor look on child
bulging belly
what are the effects of kwashiorkor
loss of appetite, brittle hair that loses color
what is components of maramus
inadequate protein and food energy
how does maramus look on child
very thin, almost elderly looking
effects of maramus
weakened muscles, impaired brain development, decreased body temp
how to calculate recommended protein intake
weight in pounds/2.2= kg
0.8*kg= protein per day