gonadal hormones, oral contraceptives, and erectile dysfunction drugs

What are the classes and subclasses of gonadal hormones, oral contraceptives, and erectile dysfunction drugs?

• estrogens and progestins

• fertility drugs

  • ovulation stimulants

• androgens

• erectile dysfunction drugs

  • phosphodiesterase inhibitors

What drug class is intended to mimic the physiologic function of endogenous hormones?

estrogen and progestins

What drug class is used for oral contraception, hormone replacements therapy, adjunctive therapy of certain cancers, hypogonadism, primary ovarian failure, amenorrhea, dysmenorrhea, endometriosis, and osteoporosis?

estrogen and progestins

What drugs are in the estrogen and progestins drug class?

• estradiol

• medroxyprogesterone

• oral contraceptives

What drug has many formulations and uses and can be PO, transdermal patch, topical, IM?

estradiol

What drug maintains high blood levels of estrogen/progesterone to inhibit release of FSH and LH?

oral contraceptives

What drugs are in the ovulation stimulants drug subclass?

• clomiphene (Clomid)

• follitropin

• menotropins

What drug class is used for induction of ovulation in anovulatory infertile women and assisted reproductive technologies?

ovulation stimulants

What drug is a nonsteroidal estrogen receptor antagonist that binds estrogen receptors causing inhibition of the negative feedback loop thus increasing LH and FSH secretion and stimulation of follicle development and ovulation (5 day treatment)?

clomiphene (Clomid)

What drugs are purified or synthesized proteins that act as FSH to stimulate follicle maturation and rupture (followed by hCG to act as LH)?

polypeptide stimulants

What drug is also used to induce spermatogenesis in men who don’t produce enough testosterone (not caused by testicular failure)?

follitropin

What drug helps with multiple follicle development and is also used to stimulate sspermatogenesis?

menotropins

What drug class is hormone replacement therapy (actions similar to endogenous androgens), anabolic action (stimulate protein synthesis), and erythropoesis (stimulate production of red blood cells)?

androgens

What drug class is used for HRT (primary hypogonadism, hypogonadotropic hypogonadism, androgen deficient impotence), metastatic inoperable breast cancer in women, combat protein catabolism and weight loss in chronic diseases, and refractory anemia?

androgens

What drugs are in the androgens drug class?

• testosterone

• methyltestosterone

• oxandrolone

• oxymetholone

What drug is used to promote weight gain with underlying conditions causing protein breakdown?

oxandrolone

What drug causes anemias to form from deficient RBC production?

oxymetholone

What drugs are in the phosphodiesterase inhibitors drug subclass?

• sildenafil (Viagra)

• tadalafil (Cialis)

What drug subclass works by selective inhibition of phosphodiesterase 5 in the penis to prevent cGMP breakdown and allow cGMP accumulation leading to arterial smooth muscle relaxation, increased blood flow, and erection?

phosphodiesterase inhibitors

What drug subclass is used for impotence?

phosphodiesterase inhibitors

What drug is also used for pulmonary atrial hypertension under the trade name Revatio (revatio not used for ED)?

sildenafil (Viagra)

What drug is also used for pulmonary arterial hypertension under the trader name Adcirca (adcirca not used for ED)?

tadalafil (Cialis)