Trauma/OBGYN Pharmacology

TXA Misoprostol Diazepam

(TXA) Is classed as a

anti-fibrinolytic medication

(TXA) Reversibly binds to

Plasminogen

(TXA) binding to plasminogen causes

A reduction of plasmin

(TXA) A reduction of plasmin caused by TXA binding =

Stops the breakdown of clots

(Misoprostol) What does a uterotonic drug aim to do?

Induce contraction or tone of uterus

(Misoprostol) Is classed as a

Synthetic prostaglandin E1 analog

(Misoprostol) Prostaglandins are produced

on demand

(Misoprostol) Prostaglandins are

• mediators of inflammation

• Immune response

• Muscle constriction and relaxation

(Misoprostol) Binds to

Prostaglandin EP2&3

(Misoprostol) Binding to Prostaglandin EP2&3 causes

Myometrial contraction

(Misoprostol) Increase in myometrial contraction results in

Decreased bleeding

(DZP) Is a

benzodiazepine

(DZP) Acts on ____-_ receptors

GABA-A

(DZP) Binds to GABA-A at a location

separate to GABA binding

(DZP) The site GABA-A and DZP bind at is known as a what site?

Allosteric

(DZP) Binding at allosteric site allows for

Increased GABA-A receptor action

(DZP) Aims to open ion channel and allow

Negative Cl Ions into neuron

(DZP) -ve cl ions in neuron mean

membrane potential closer to zero = less likely for neurons to fire action potential

(CO-AMOX) Contains which medications?

• Amoxicillin

• Clavulanic Acid

(CO-AMOX) Amoxicillin belongs to which antibiotic group?

Penicillin

(CO-AMOX) Clavulanic acid is a

B-Lactamase inhibitor

(CO-AMOX) What is the active compound?

Amoxicillin

(CO-AMOX) Amoxicillin is a

Beta-Lactam antibiotic

(CO-AMOX) Beta lactam antibiotics target

• Gram positive cocci

• Gram negative aerobes

(CO-AMOX) Amoxicillin is known as a

Bacteriolytic drug

(CO-AMOX) Amoxicillin binds to which proteins?

Multiple Penicillin binding proteins

(CO-AMOX) Amoxicillin inhibits

Final transpeptidation step in peptidoglycan synthesis

(CO-AMOX) Binds to and inteferes with cross linkage of

peptidoglycan chains

(CO-AMOX) Peptidoglycan chains are

necessary for bacterial wall strength and rigidity

(CO-AMOX) Amoxicillin essentially

Weakens cell and causes bacterial cell wall death

(CO-AMOX) Cell wall death is caused by

Osmolarity instability and rupture