cytoskeleton

microtubule functions

• organization in cytosol

• tracking transport of vesicles + organelles

• movement of chromosomes in mitosis

• strucutral compontent of cilia/flagella

microtubule components

a-tubulin and B-tubulin

a-tubulin attaches to the ___ end

plus

B-tubulin attaches to the ____ end

minus

dynamic instability

microtubules grow/shrink independent of their neighbors

GTP bound microtubules favor _____

assembly

GDP bound microtubules favor ____

disassembly

catastrophe

loss of GTP tubulin cap and rapid depolymerization

kinesins

motor proteins that move towards the plus end

dyneins

motor proteins that move towards the minus end

kartagener’s syndrome

mutation in the dynein motor arm that immobilizes cilia and causes infertility

capping proteins

stabilize microtubules to prevent them from randomly shrinking