Hematology Final

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A set of laboratory practices that ensure reliable outcomes for patient results is

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1

A set of laboratory practices that ensure reliable outcomes for patient results is

Quality Assurance

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2

which of the following is the most important element of standard precautions?

Handwashing

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3

Production, development, and maturation of all blood cells is called?

Hematopoiesis

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4

The development order for Red Blood Cells (RBCs) is which of the following?

Pronormoblast, basophilic normoblast, polychromatophilic normoblast, orthochromic normoblast, reticulocyte, erythrocyte

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5

How many parameters does a CBC have?

9

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6

When viewing a slide with a 100x objective and 10x ocular lens, what is the total magnification?

1000

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7

The most stable parameter of a CBC

MCV

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8

Intrinsic factor, secreted by the parietal cells of the stomach, is necessary for

absorption of b12

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9

Pancytopenia means

Low WBC, RBC, PLT

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10

n which of the following conditions should a CBC be placed at 37 degree C for 15-30 minutes before running the test?

Cold Agglutinin Syndrome

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11

A male with sickle cell (SS) and a female sickle cell trait (AS) have what likelihood of having a child with sickle cell anemia?

50%

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12

It is common to see increased RBC inclusions post splenectomy

True

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13

Hypersegmentation means

Neutrophil has more than 5 lobes

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14

An enzyme deficiency associated with a moderate to severe hemolytic anemia after the patient is exposed to certain drugs or infections and characterized by red cell inclusions formed by denatured hemoglobin is:

G6PD deficiency

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15

In which of the following, are smudge cells usually present?

CLL

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16

Which of the following is an abnormal protein that is is an overproduction of IgM?

Waldenstrom's Macroglobulinemia

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17

Reed-Sternberg cells are present in

Hodgkin's Lymphoma

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18

Lymphocytes in CLL are

increased in number and nonfunctional

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19

What is the cytochemical stain used to diagnosis Hairy cell leukemia?

TRAP

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20

Which disease results in an accumulation of plasma cells in the bone marrow?

Multiple Myeloma

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21

What is the red cell condition known for looking like a stack of coins and caused by abnormal proteins?

Roleaux

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22

Bence-Jones protein is found in the urine of patients with

Multiple Myeloma

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23

Preleukemia, Dysmyelopoietic syndrome, Oligoblastic anemia, and Refractory anemias are all other names for what syndromes?

Myelodysplastic syndromes

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24

All of the coagulation factors except a portion of factor VIII are produced in

The liver

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25

A patient with classic Hemophilia A is deficient in

Factor VIII

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26

Which lab test measures the extrinsic pathway?

PT

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27

Which lab test measures the intrinsic pathway?

PTT

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28

The anticoagulant of choice for coagulation testing is (blue-top tube)

Sodium citrate

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29

The blood–to–anticoagulant ratio for coagulation testing is

9:1

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30

Which of the following is a normal platelet count?

212,000

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31

The most common drug related platelet abnormality is due to

aspirin

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32

Any group of disorders in which a particular clotting factor is decreased is referred to as

Hemophilia

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33

The principal substrate of the coagulation and fibrinolytic system isis

fibrinogen

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34

Which of the following short-term anticoagulant drugs, administered by intravenous infusion, is monitored by the PTT value?

Heparin

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35

The international normalized ratio (INR) is useful in:

monitoring coumadin therapy

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36

What is the expected Prothrombin (PT) result in a patient who is on coumadin and is stable?

26 seconds

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37

Obstetrical complications like retained placenta or abruption placenta are a leading cause of:

DIC

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38

A normal cerebrospinal fluid has a clear and colorless appearance.

True

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39

Cerebrospinal fluids (CSF), synovial fluids, and serous fluids (pericardial, pleural and peritoneal) have cellular elements which often change in predictable patterns with disease states.

True

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40

What department is the CSF tube labeled 3 routinely sent to?

Hematology

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41

A total CSF cell count on a clear fluid should be:

counted undiluted

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42

The purpose of adding albumin to body fluids before cytocentrifugation is to:

increase the cell yield and decrease cellular distortion

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43

Before testing, viscous synovial fluid should be treated with :

hyaluronidase

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44

The procedure for collecting synovial fluid is called:

Arthrocentesis

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45

The procedure for collecting pleural fluid is called:

thoracentesis

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46

A milky-appearing pleural fluid indicates:

thoracic duct leakage or chronic inflammation

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47

A significant cell found in pericardial or pleural fluid that should be referred to cytology is a:

mesothelioma cell

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48

The most characteristic change seen in the peripheral smear of a patient with multiple myeloma is the presence of:

Roleaux

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49

The JAK2 chromosomal mutation is associated with

Polycythemia vera

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50

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

Hypercellular bone marrow with greater than 20% blasts

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51

_____ is predominantly a disease of children.

ALL

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52

An autosomal disorder that manifests itself with large lysosomal inclusions, recurring infections, and albinism is

Chediak-Higashi Syndrome

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53

The best corrective action for a patient who exhibits platelet satellitium on peripheral blood smear is to

redraw the sample in sodium citrate

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54

Toxic vacuolization occurs most frequently in

neutrophils

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55

Patients with hemophilia A or B have abnormal results in which coagulation assay?

PTT

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56

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?

Factor Assays

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57

Infectious mononucleosis is caused by the EBV virus, which infects B lymphocytes.

True

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58

In the Hematology lab, it is necessary to wear PPE in the following circumstance

When handling any specimen

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59

The variability of events that can occur to an unknown sample before analysis

preanalytical

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60

Delta Check

QC method for comparing a patient's own current results with previously verified results

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61

reference intervals

values that have been established for a particular analyte, method, or instrument in a particular patient population.

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62

which is a normal hemoglobin value

15 g/dL

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63

used to monitor performance of a method after callibration

Control Materials

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64

Primary purpose of hemoglobin

deliver oxygen

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65

Morphological classification of anemia is determined by

Red cell indices

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66

values outside of the reference range that need immediate action are

critical results

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67

Which of the following tests monitors RBC production

reticulocyte count

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68

in an adult, the usual location for obtaining a bone marrow aspirate is the

illiac crest

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69

The proper definition of a standard is

solutions with a known amount of (fixed) analyte

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70

the majority of iron found in an adult is found in

hemoglobin

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71

Heinz bodies are

unable to be seen with typical, commonly used staining methods

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72

average lifespan of an RBC

120 days

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73

Howell-jolly bodies are remnants of:

DNA

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74

An early indicator of an anemic process may be

RDW

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75

hypochromia is used to define

decrease in hemoglobin content of RBCs

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76

An unusual finding in intravascular hemolysis is

hemoglobinuria may be present

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77

normal adult hemoglobin consists of how many heme molecules?

four

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78

Hormone responsible for RBC production

erythropoietin/EPO

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79

Where is EPO produced?

the kidneys

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80

another name for orthochromic normoblast

nRBC

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81

Which settings on the microscope are used for focusing?

coarse and fine adjustments

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82

The most important preanalytical step

Patient identification

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83

Function of the spleen in adults

removing imperfect and old RBCs

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84

Sickles that are able to be reoxygenated are labelled

reversible

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85

macrocytes and hypersegmented neutrophils indicate which type of anemia?

megaloblastic anemia

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86

Alpha thalassemia major results from

not enough functional hemoglobin A produced

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87

Beta thalassemia major results from

no Hemoglobin A being synthesized

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88

aplastic anemia is characterized by

pancytopenia and reticulocytopenia

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89

What test is used to confirm a positive sickle cell screening test

Hemoglobin electrophoresis

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90

What red cell inclusion may be present post-splenectomy

Howell-Jolly bodies

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91

Hereditary pyropoikilocytosis is a red cell membrane defect characterized by

misshapen budding fragmented cells

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92

Iron deficiency anemia is characterized by

decreased serum iron, decreased serum ferritin, increased TIBC

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93

Macrocytes typically seen in megaloblastic anemias are

oval shaped

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94

which organ is responsible for pitting RBCS

spleen

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95

which antibody is associated with paroxysmal cold hemoglobinuria

anti-p

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96

Which red cell index values are associated with megaloblastic anemias

MCV 125, MCH 30, MCHC 34%

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97

Sickle cell trait is achieved through

heterozygous inheritance of hemoglobin S

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98

pernicious anemia is a subset of which of these anemias?

megaloblastic anemia

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99

Individuals with a vitamin b12 defieciency will require

life long therapy

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100

Which hemoglobin will show crystals appearing like bars of gold?

hemoglobin C disease

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