Poxvirus, Papilloma virus, African Swine fever

Largest

Poxvirus are the ____ virus?

Double stranded DNA

What kind of virus are poxvirus?

Cytoplasma

Where does poxvirus replicate?

Lytic or non-cytolytic

How are virons released by the poxvirus?

Vesicles/ scabbing after 3d-3m incubation

What are clinical signs of poxvirus?

Mimicry

Down regulation of:

MHC I, CD4, INF, TNF, IL-10 and complement

What are ways poxvirus evade the immune system?

Foot and mouth dz

What is an important differential of bovine papular stomatitis?

oryctolagus

Myxomatosis will affect which type of rabbit more: sylvilagus or oryctolagus?

Old world (not llamas/ alpacas)

Camelpox will primarily affect what type of camelids?

Aerosole

Mechanical vectors

Direct contact/ fomites

How is Poxvirus transmitted?

Vax

Control vectors

Isolation/ slaughter

What is prevention for poxvirus?

Myxomatosis

Lumpy skin dz (cattle)

Sheep/goat pox

camelpox

Name the four foreign animal poxvirus?

Cow pox

Contagious ecthema (ORF)

camelpox (rare)

Sealpox

Name the four zoonotic pox dz?

Oronasal mucosa

What tissues do cowpox and ORF target?

Skin

Lymphocytes

What tissues do myxomatosis target?

Skin

What tissue does lumpy skin dz target?

Skin and Resp

What tissue does sheep/goat and camel pox target?

Bovine papilomavirus type 1/2

What causes equine sarcoids?

Non-enveloped - capsid only

Papilloma viruses are ___ unlike pox viruses that have a lipid coating?

Basal squamous epithelium - replicate in nucleus

What region do papillomaviruses need to infect?

Non-cytolytic - budding

How do virons release from cells infected w/ papillomavirus

Proliferative lesions (warts) of the epithelium

What are clinical signs of papilloma viruses?

Do not stimulate the immune response

- noncytolitic

- inhibit IFN pathway

How do papillomaviruses evade the immune system?

Excision

Cryosurgery

Radiation/ chemotherapy

Spontaneous regression

How are papilloma viruses treated?

Foreign - is close since recent appearance in Dominican Republic

African swine fever is considered a ___ dz in America?

Biologic arthropod vector - ornithodoros

Contact w/ infected domestic/ wild swine

contact w/ infected pork products

How is African swine fever transmitted?

Cytoplasma

Where does African swine fever replicate?

Non-cytolytic

How are virons released from cells infected w/ African swine fever?

Sudden death

What occurs in peracute infections of African Swine Fever?

Fever

Cutaneous hemorrhage

Splenomegaly

What occurs in acute infections of African Swine Fever?

Pneumonia

Wt loss

Joint swelling

What occurs in Subacute infections of African Swine Fever?

Depop/Decontaminate/Repop

Prevent exposure to vectors/ feral swine

NO VAX

What are methods of control for African Swine Fever? ?

Differentiate Infected from Vaccinated Animals - sep true infections from vax in endemic areas

What is DIVA?