Dose Response Curves

define efficacy

the intensity of a response the drug can produce

if a plot comes out higher on efficacy what does it represent

analgesia

T or F: drugs can have the same EC50 but different efficacy

true

define potency

amount of drug necessary to produce an effect of a given magnitude

T or F: if two drugs have different EC50s they have the same potency

false

T or F: two or more drugs can have different potency but same efficacy

true

what is ceiling effect

once the drug reaches the maximum response

what is threshold effect

once the drug reaches minimum quantity to have therapeutic effects

T or F: you need to be careful with redosing because you could still have drug left over in your body

true

what does the addition of a competitive antagonist do to dose response curves

shifts them to the right

what do competitive antagonists usually do to potency

increase it

what do non-competitive antagonists do to dose response curves (shift)

shift it down

what does the addition of a non-competitive antagonist do to efficacy of a drug

make it so it cant reach maximum threashold

what is oral repeated dosing based on

½ life