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primary with a strong base/weak nucleophile (ex: bulky)
E2
secondary with a strong base/weak nucleophile (ex: bulky)
E2
tertiary with a strong base/weak nucleophile (ex: bulky)
E2
primary with a strong base (pka>12)/strong nucleophile ex: HO-, MeO-
SN2 for the most part
secondary with a strong base (pka>12)/strong nucleophile ex: HO-, MeO-
E2
tertiary with a strong base (pka>12)/strong nucleophile ex: HO-, MeO-
E2
primary with a weak base/strong nucleophile (ex: I-) pKa<12
SN2
secondary with a weak base/strong nucleophile (ex: I-) pKa<12
SN2
tertiary with a weak base/strong nucleophile (ex: I-) pKa<12
SN1
tertiary with a weak base/weak nucleophile (ex: CH3OH)
SN1, E1 if high temp
SN2 product stereochemistry
only inverted product formed R→S
E2 product stereochemistry
both E and Z are formed unless the B carbon where the hydrogen is removed only has one hydrogen
SN1 product stereochemistry
both S and R are formed with generally more inverted product
E1 product stereochemistry
both E and Z formed (with more of the largest groups on opposite sides of the double bond)