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which layer of the heart contains the cardiac conduction system
endocardium
semilunar valves
control blood flow to the major arteries
- pulmonic (R) and aortic (L) valves
atrioventricular valves
control blood flow from atria to ventricles
- tricuspid (R) and mitral (L) valves
cardiac cycle
mechanical events that occur to pump blood
- two phases: diastole and systole
phases of diastole
- rapid-filling phase: AV valves pop open (high pressure in atria) + ventricles fill rapidly
- diastasis: flow into ventricles slows (pressures are equalizing)
- atrial kick: atria contract to force remaining blood into ventricles + valves shut (higher pressure in ventricles)
phases of systole
- isovolumetric contraction: all valves shut + ventricles start to contract (no blood flow yet)
- ventricular ejection: semilunar valves open + blood fills arteries
- protodiastole: blood flow slows (pressures are equalizing)
- isovolumetric relaxation: ventricles relax + valves close (higher pressure in arteries)
blood flow through systemic circulation
aorta --> arteries --> arterioles --> capillary bed --> venules --> veins --> vena cava
when is the heart muscle able to receive its own blood supply (through coronary arteries)
diastole
left main coronary artery (and branches)
provides blood flow to the walls of left ventricle
- perfuses about 60% of myocardium
- has two main branches: left anterior descending + circumflex
left anterior descending artery supplies
anterior wall of left ventricle
circumflex artery supplies
lateral wall of left ventricle
right coronary artery supplies
right ventricle and inferior wall of left ventricle
posterior descending artery arises from
- right coronary artery (in 70% of people)
- circumflex artery (in the other 30% of people)
types of heart cells
- contractile cells
- conduction system cells
control of the heart conduction system
- conduction system cells CREATE and conduct impulses to regulate cardiac cycle
- influenced by the autonomic nervous system
sympathetic NS
mediated by norepinephrine
- released by adrenal gland
- increases heart rate and blood pressure
- causes pupils to dilate
- slows digestion
parasympathetic NS
mediated by acetylcholine
- secreted as result of stimulation of vagus nerve
- slows heart rate and decreases blood pressure
- enhances digestion
cardiac cells at rest are electrically
negative on the inside (compared to outside)
cardiac cell steps of depolarization and repolarization
- negatively charged resting cardiac cell is polarized (Na+ primarily outside cell, K+ inside)
- depolarization: when stimulated by electricity, cell becomes positively charged (lots of Na+ rushes in, some K+ leaks out)
- electrical wave courses from cell to cell spreads throughout the heart (positive ions move to adjacent cells)
- repolarization: during cell recovery, Na+ and K+ shift back to their original places (via Na+/K+ pump)
depolarization should result in
heart muscle contraction
repolarization should result in
heart muscle relaxation
electrical stimulus precedes
mechanical response
- no heart beat without first having had depolarization
- however, electrical stimulus does not guarantee mechanical response
action potential phases
- phase 4: cardiac cell at rest; resting membrane potential is -90mV
- phase 0: cardiac cell is stimulated; depolarization occurs
- phase 1: Ca2+ released to cause ventricular contraction; early repolarization occurs
- phase 2: plateau phase
- phase 3: Na+ and K+ return to normal; rapid ventricular repolarization
what is flatline
indicates electrical silence
what EKG finding corresponds with phase 0
QRS complex
what EKG finding corresponds with phase 1
ST segment
what EKG finding corresponds with phase 2
where waveform levels off (before T wave)
- part of ST segment
what EKG finding corresponds with phase 3
T wave
absolute refractory period
no stimulus can cause depolarization
relative refractory period
strong stimulus can cause depolarization
supernormal period
even a weak stimulus can cause depolarization
- cell is "hyper"
when does absolute refractory period occur
from beginning of QRS to beginning of T wave
when does relative refractory period occur
top of T wave
when does supernormal period occur
end of T wave
P wave
- atrial depolarization
- normal P wave is small, rounded, and upright
Ta wave
- atrial repolarization
- not usually seen, as it occurs simultaneous with QRS
QRS complex
- ventricular depolarization
- normal QRS spiked in appearance, consisting of one or more deflections from the baseline
T wave
- ventricular repolarization
- normal T wave is broad and rounded
U wave
- late ventricular repolarization
- not normally seen
- should be shallow and rounded, the same deflection as the T wave
PR segment
flat line between P wave and QRS complex
ST segment
flat line between QRS complex and T wave
baseline
flat line between the T wave of one beat and the P wave of the next beat
- aka isoelectric line
Q wave
- negative deflection (wave) that occurs before a positive deflection
- can only have one (if present, must be first wave of QRS complex)
R wave
- any positive deflection
- can be more than one (second one is R prime or R')
S wave
- negative deflection that follows an R wave
QS wave
- negative deflection with no positive deflection at all