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TYPICAL
Ratio: Prochlorperazine is a 1st Generation Anti-Psychotic | ANTI-EMETIC
ATYPICAL OR TYPICAL?
Prochlorperazine
DOC for Hiccups
Uses of the drug:
Chlorpromazine
Antihistamine
Uses of the drug:
3. Promethazine
Management of Irritability for Autistic
Uses of the drug:
Aripiprazole
For tardive dyskinesia
Uses of the drug:
Clozipine
a. Haloperidol
Which of the ff drug has the highest Dopamine-2 Receptor blockade?
a. Haloperidol
b. Clozapine
c. Aripiprazole
d. Chlorpromazine
b. Atypical Anti psychotic
Clozapine is a
a. Typical antipsychotic
b. Atypical Anti psychotic
c. anti seizure
d. anti-parkinsonism
b. Olanzapine
Atypical anti-psychotic
a. Chlorpromazine
b. Olanzapine
c. Haloperidol
d. Thioridazine
PSYCHOSES/SCHIZOPRENIA
exhibit gross disturbances in their comprehension of reality, as evidenced by false perceptions (hallucinations) and false beliefs (delusions)
mesoCORTICAL pathway
Dopamine travels from the midbrain to the prefrontal lobe cortex
↓ neurotransmission of DA
Problem w/ mesoCORTICAL pathway
anhedonia,
alogia,
apathy
mesoCORTICAL pathway can result to (-) symptoms:
increase DA neurotransmission by giving atypical
Goal therapy for mesoCORTICAL pathway’s problem:
mesoLIMBIC pathway
Dopamine travels from the midbrain tegmental area to the nucleus accumbens
↑neurotransmission of dopamine
Problem w/ mesoLIMBIC pathway
agitation,
delusion,
disorganized thinking,
speech,
schizophrenia
mesoLIMBIC pathway can result to (+) symptoms:
decrease DA neurotransmission by giving typicals
Goal therapy for mesoLIMBIC pathway’s problem:
NIGROSTRIATAL PATHWAY
The pathway from the substantia nigra to the striatum (involved in the coordination of body movements)
Inhibition of this pathway causes the extrapyramidal side effects of antipsychotic drugs (typicals)
Problem w/ NIGROSTRIATAL PATHWAY
TUBEROINFUNDIBULAR PATHWAY
The pathway from the hypothalamus to the pituitary inhibits the release of prolactin.
HYPERPROLACTINEMIA
Inhibition of TUBEROINFUNDIBULAR PATHWAY pathway leads to:
D2 > 5HT2
Typical receptor blockade
5HT2 > D2
Atypical has a great affinity in
Effective
Effective or Not Effective
Typical in positive symptoms
Effective
Effective or Not Effective
Atypical in positive symptoms
Less effective
Less effective or more Effective
Typical in negative symptoms
More effective
Less effective or more Effective
Atypical in negative symptoms
More case
Less effective or more Effective
Typical in Extrapyramidal effects
Less case
Less effective or more Effective
Atypical in Extrapyramidal effects
More case
Less effective or more Effective
Typical in Tardive Dyskinesia
Less case
Less case or more case
Atypical in Tardive Dyskinesia
TRUE
TRUE or FALSE
Atypical agents is beneficial to schizophrenia but it’s expensive
Haloperidol
highest activity to block dopamine 2
ANTIPSYCHOTIC DRUGS
reduce psychotic symptoms and improve the behavior of schizophrenic patients
aka neuroleptic drugs because they suppress motor activity and emotional expression
neuroleptic drugs
ANTIPSYCHOTIC DRUGS is also known as _ because they suppress motor activity and emotional expression
Typical Antipsychotic Agents
1st generation Antipsychotic Agents
EPS,
Tardive dyskinesia,
Anticholinergic effects (Thioridazine),
Neuroleptic malignant syndrome
A/E of Typical Antipsychotic Agents
Fluphenazine
Trifluoperazine
Thiothixene
Haloperidol
High Potency Typical Antipsychotic Agents
Chlorpromazine
Thioridazine
Low Potency Typical Antipsychotic Agents
Loxapine
Intermediate Potency Typical Antipsychotic Agents
Clozapine
Olanzapine
Risperidone
Aripiprazole
2nd generation Antipsychotic Agents
Clozapine
the first of a new generation of atypical antipsychotic drugs
less EPS
sedation & autonomic side effects, potentially fatal Agranulocytosis
Clozapine A/E:
Olanzapine
causes fewer ANS
NO agranulocytosis reports
S/Es: sedation, weight gain
sedation, weight gain
Olanzapine S/E
Risperidone
properties similar to olanzapine, but it appears to cause less sedation
S/Es: orthostatic hypotension cardiotoxicity (QT interval prolongation
Aripiprazole
partial agonist at dopamine and 5-HT1A receptors
first drug approved to treat irritability in autistic children
orthostatic hypotension cardiotoxicity (QT interval prolongation)
Risperidone S/Es:
Chlorpromazine
DOC for hiccups
Haloperidol
Tx for Tourette
Clozapine
5HT2 = D4 > D2