Hema 2: Lymphoproliferative diseases and Lymph nodes

[Lymphoma]

• Weight loss and loss of appetite [2]

• Lymphadenopathy

• Exophthalmos

• dyspnea and esophageal destruction

• diarrhea, obstruction or melena

Non specific signs (2)

Painless enlargement of lymph nodes:

Other signs depend on anatomic location:

Retrobulbar lymph nodes:

Thymus:

Alimentary:

• soft to firm, bulge on cut surface, homogenous, pale tan to white

• foci of necrosis or hemorrhage

• often firmly attached (fibrosis) to surrounding tissue

Gross lesions [Lymphoma][3]

1. Organomegaly: diffuse organ enlargement

2. Multiple tan-white to pink nodules within organs

3. thickening of walls of tubular organs

Identify.

Neoplastic round cells efface the normal structure

[Microscopic lesion of Lymphoma]

Uniform population of small lymphocytes

[Microscopic lesiom of Lymphoma]

Anaplastic round cells with mitoses, anisocytosis, anisokaryosis

[Microscopic lesion of Lymphoma]

Cutaneous

[Canine Lymphoma]

Thymic

[Canine lymphoma]

Alimentary

[Canine lymphoma]

Malt and Tonsils

[Canine lymphoma]

• Feline lymphoma

• Multicentric

Most common malignant neoplasm of cats

Alimentary

[Feline lymphoma]

• Feline leukemia virus. (FLV)

• mediastinal and multicentric T cell lymphoma

• [pic] Thymic/Mediastinal

Feline lymphoma is associated with ______

FeLV is associated with ____

Enzootic bovine lymphoma

Heart

Affected site in EBL

Uterus

Affected site in EBL

Abomasum

Affected site in EBL

Spinal canal

Affected site in EBL

[Left] heart, uterus

[Right] Abomasum, Spinal canal

Affected site of EBL

Calf form

1. 6

2. symmetrical

3. bone marrow

4. multicentric

What form is this? [Sporadic bovine lymphoma]

1. less than ___ months of age

2. _________ lymphadenopathy

3. ________ involvement

4. ______ lymphoma

Juvenile = Thymic form

1. Young , 2

2. Mediastinal

What form is this? [Sporadic bovine lymphoma]

1. ______ ( < ) beef cattle

2. _______ thymic mass

Cutaneous form

1. 2-3

2. raised skin lesions

3. waning

4. 12-18

What form is this? [Sporadic bovine lymphoma]

1. ______ year old cattle

2. plaques or nodular, _____

3. waxing and ___

4. survive ____ to ____ months

Porcine lymphoma

1. 1

Most common neoplasm of pigs

1. often < __ old

Multicentric lymphoma

[Porcine Lymphoma]

Equine lymphoma

1. Multicentric, cutaneous, alimentary form

Identify.

1. Common forms of this (3)

1. Lymphoid atrophy

2. lymph node degeneration

3. lymph node hypoplasia

1. Lymphadenitis

2. Lymphoid hyperplasia

3. Hyperplasia of the monocyte/macrophage system

4. Primary neoplasia

5. Secondsry neoplasia

Enlargement of the right retropharyngeal LN of Sheep

Identify

Normal lymph node

Identify

Reactive lymphoid hyperplasia

1. Nodes

2. bulge

Identify [pic]

Gross lesion:

1. Moderate enlargement of ____

2. May ___ on cut section

1. lymphoid follicles, germinal

2. T, paracortex

3. plasma, medullary cords

[Benign reactive hyperplasia]

Histology: (3)

1. Proliferation of ________ with prominent _____ centers

2. Increased ___ cells in the ____

3. +/- increased _____ cells in the ______

Cervical and sternal lymphadenitis with sepsis

[acute lymphadenitis] Identify the pic

• chronic lymphadenitis

• [pic] Rhodococcus equi in foal

what kind of lymph node inflammation?

Identify the pic

• chronic suppurative lymphadenitis

1. swollen, pus, lymph node abscess

what kind of lymph node inflammation?

Gross lesion:

1. _____ lymph node with ___filled center =

chronic suppurative lymphadenitis

Identify

Equine strangles

Identify

Chronic suppurative lymphadenitis ( Caseous lymphadenitis )

Identify

Goat, Caudal mediastinal LN abscesses

[chronic suppurative lymphadenitis]

Caseous. lymphadenitis

Identify

Nodular granulomatous lymphadenitis

Identify

[Granulomatous lymphadenitis]

Diffuse granulomatous lymohadenitis

Identify

[Granulomatous lymphadenitis]

Bovine Tuberculosis

1. Enlargement, yellow-tan gritty

Identify

1. Gross: _____ of the lymph node with a single to multiple discrete _______ nodules

central, epitheloid macrophages, giant cells

[Bovine tuberculosis]

Histology: Granulomas with ____ necrosis and mineralization surrounded by ____ and multinucleated ______

acid fast bacilli within macrophages

Identify