Anterior Pituitary Hormones

TSH

thyroid stimulating hormone

What does TSH do?

increases TH levels (T3/T4)

What are the affects of TSH?

normal development, maintain metabolism

ACTH

adrenocorticotropic hormone

What does ACTH do?

stimulates adrenal cortex to increase glucocorticoid hormone secretion (cortisol)

When do ACTH levels peak?

morning

What are the triggers of ACTH?

fever, hypoglycemia, STRESS

What is POMC?

proopiomelanocrtin

What does POMC do?

precursor protein, cleaves into 4 other active molecules

What is POMC a source of?

ACTH, lipotropins, endorphins, analgesia, MSH

FSH

follicle stimulating hormone

How does FSH work in females?

follicle maturaiton, estrogen secretion in ovary

How does FSH work in males?

produce sperm in testes

LH

lutenizing hormone

How does LH work in females?

ovulation and progesterone secretion

How does LH work in males?

produce testosterone in interstitial cells and stimulates gonads (ovary and testes), activate at puberty

TSH tropic?

yes

ACTH tropic?

yes

FSH tropic?

yes

LH tropic?

yes

GH tropic?

no

PRL tropic?

no

Where are anterior pituitary hormones that are not tropic released from?

acidophil cells

GH

growth hormone

What is another name for GH?

somatotropin

What does GH do?

increased tissue growth, bone and skeletal muscle

Is GH anabolic or exergonic?

anabolic

When do we have the highest production of GH?

in sleep, puberty

What are other factors that regulate growth?

genetics, nutrition, and sexual hormones

What are the 2 conditions that come with hyper secretion of GH?

gigantism and acromegaly

Describe gigantism.

increased GH before epiphyseal plates close, proportionate enlargement

Describe acromegaly.

increased GH after epiphyseal plates closed (affects face-above eye, jaw, hands, feet)- also thick skin, broad nose, enlarged tongue

What is the condition that comes with hypo secretion of GH?

pituitary dwarfism

Describe pituitary dwarfism.

decreased GH, small stature, may be proportionate or not

PRL

prolactin

What does prolactin do?

suckling action; milk production in mammary gland of lactating females

What is the most common reason for excess secretion of PRL?

anterior pit tumor