Exam 2 - Chapter 10, immunologic memory

when b cells are activated by an initial invade, what kinds of B cells are made

1. short-lived plasma cells

2. long-lived plasma cells

3. central memory b cell

what cells must help B cells to become memory cells

follicular helper t cells

what cytokine is released by Tfh to lead to b cell differentiation

IL-21

where are long lived and short lived plasma cells produced

germinal centers of lymphoid follicles in secondary lymphoid organs

where do short-lived plasma cells travel to? what do they produce?

bone marrow and spleen

antibodies

where do long-lived plasma cells travel to? what do they produce?

bone marrow, GI, respiratory mucosa

IgG and specific antibody classes based on exposure

which B cell type provides life-long antibody protection

long-lived plasma cells

is the primary or secondary response to pathogen higher

secondary

where do central memory b cells live? how quickly do they proliferate? what is their function?

secondary lymph organs

slowly

maintain pool of central memory b cells which can quickly proliferate when invader is encountered again to produce short-lived plasma cells

where do effector t cells travel to? how long do they live?

tissue to fight, apoptosis after few days

where do tissue resident memory t cells travel to? how long do they live?

tissues, remain here for at least 10 years waiting for another attack

where do effector memory t cells circulate? how long?

blood and lymph, 10 years, just waiting

what is the name of activated t cells that stay in secondary lymphoid organs and bone marrow

central memory t cells

what do central memory t cells do when there is an attack

activate, proliferate, head into tissue to fight

are B or T memory cells more specific? why?

B, somatic hypermutation

is there a t cell equivalent to a long-lived plasma b cell

no

t/f

no two humans have the exact same adaptive memory

true

t/f

all humans have essentially the same innate memory

true