PHRM 825 Exam 2- Androgens

What reaction occurs with 5a-reductase

testosterone → 5a-dihydrotestosterone

why is 5a-dehydrotestosterone preferred over testosterone

5a-dehydrotestosterone is more potent and is a major active androgen

physiological effects of testosterone

changes during puberty

penile and scrotal growth

thicker and oiler skin

pubic, axillary, and beard hair

deepening of voice

skeletal growth followed by epiphyseal closure

increase in lean body pass → positive nitrogen balance

stimulation growth followed by epiphyseal closure

stimulation and maintenance of sexual function

decrease in HDL levels

why do we use synthetic androgens instead of testosterone

testosterone is absorbed easily but inactivated very quickly

adverse effects of testosterone in women

hirsutism, acne, amenorrhea, clitoral enlargement

adverse effects of testosterone in men

acne, sleep apnea, gynecomastia, azoospermia and testicular atrophy, increased aggressiveness and psychotic symptoms

5a-reductase inhibitors

antiandrogens

block the conversion from testosterone to 5a-dihydrotestosterone

5a-reductase inhibitors

type of antiandrogens

5a-reductase inhibitors, steroidal inhibitors, non-steroidal inhibitors