HMG-COA REDUCTASE INHIBITORS (STATINS)

What are Statins used to treat?

first line drug to treat dyslipidemia

What is the primary action of Statins?

They block HMG-CoA reductase, leading to decreased liver synthesis of cholesterol.

What is the prototype drug for Statins?

Atorvastatin

What is the use for Atrovastatin?

hypercholesterolemia.

what are some serious adverse effect of Statins.

Muscle problems, including myalgia, myositis, and rhabdomyolysis, dark urine

What route is Atorvastatin given by?

Oral

Which special population should avoid Statins?

Pregnant women

What should be monitored when a patient is on Statins?

Cholesterol levels and liver function tests (LFTs).

What serious interaction increases the risk of myopathy in Statin users?

Grapefruit juice

What dietary modifications should patients on Statins consider?

Maintain a low-fat diet and incorporate oats and exercise.

When should a Statin be held according to nursing considerations?

If the patient experiences muscle pain, dark urine, or fatigue.

What is the risk of Rhabdomyolysis (muscle breakdown) associated with?

High statin doses, renal disease, and interactions with other drugs.

Which Statin should not be used with kids?

Pravastatin.

What should patients of childbearing age be taught regarding Statins?

use birth control

What are some other Statins?

simvastatin, lovastatin, rosuvastatin, pitvastatin