EXCITATION Neuromuscular Transmission at the NMJ

1) Action potential arrives at the _________ of a motor neuron and causes ______________________.

synaptic end bulb, opening of voltage-gated Ca2+ channels

2) _____________ containing the neurotransmitter _______________ undergo exocytosis

Synaptic vesicles, acetylcholine (ACh)

3) ACh is released into the _________ and binds to ___________ on the motor end plate (part of sarcolemma)

synaptic cleft, ACh receptors

4) ACh receptors open and allow _____ to enter the muscle fiber, generating an ____________ on the sarcolemma

Na+, action potential (AP)

5) ACh is quickly broken down to acetate and choline by ________________.

acetylcholine esterase (AChE)