Clotrimazole/Betamethasone T300 26-27

Clotrimazole/Betamethasone

Lotrisone

Clotrimazole/Betamethasone Drug Class

Anti-infective/Anti-inflammatory Combination

Clotrimazole/Betamethasone Dosage Forms

Topical Cream: (Clotrimazole/Betamethasone) 1%/0.05%;

Topical Lotion: (Clotrimazole/Betamethasone) 1%/0.05%

Clotrimazole/Betamethasone Dosing By Indication

1. Tinea: Adults and Children ≥17 y of age, apply to affected area bid, for a max of 2 wk (for tinea corporis or tinea cruris) or 4 wk (for tinea pedis)

Clotrimazole/Betamethasone Off Label Uses

None

Clotrimazole/Betamethasone MOA

Clotrimazole inhibits biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane and altering its permeability. Betamethasone dipropionate is a corticosteroid that stimulates synthesis of enzymes thought to be responsible for anti-inflammatory effects.

Clotrimazole/Betamethasone Common Adverse Effects

None known

Clotrimazole/Betamethasone Efficacy Monitoring Parameters

Resolution of erythema and pruritus. Improvement in erythema and pruritus usually occurs within 3-5 d. If no improvement is seen after 1 wk of treatment for tinea cruris or tinea corporis, or after 2 wk of treatment for tinea pedis, then the diagnosis should be reviewed.

Clotrimazole/Betamethasone Safety Monitoring Parameters

Seek medical attention if severe skin irritation or rash.

Clotrimazole/Betamethasone Key Counseling Points

Apply thin layer to affected area. If using lotion, shake well before use.

Clotrimazole/Betamethasone Clinical Pearls

Patients receiving combination therapy show an earlier, better clinical response than patients treated with clotrimazole cream or betamethasone cream alone. Use is not recommended for patients under the age of 17 y due to increased systemic absorption and risk for adrenal suppression. Cure rates with clotrimazole/betamethasone are at least as good or better as compared to clotrimazole alone. Do not use with occlusive dressings or on larger areas. This can lead to systemic absorption of betamethasone and HPA suppression.